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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > CAROVERINEHYDROCHLORIDE
CAROVERINEHYDROCHLORIDE structure, CAS 55750-05-5

CAROVERINEHYDROCHLORIDE

CAS Number55750-05-5

SynonymsCaroverine hydrochloride; Spasmium; P 201-1; Tinnex; Spadon; Caroverine HCl

Molecular FormulaC22H28ClN3O2

Molecular Weight401.93000

Purity98.00%%

Density1.11g/cm3

Boiling Point521.2ºC at 760mmHg

Melting Point

Flash Point

Appearance

EINECS

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Cat. No.: 2A-9092125 Purity: 98.00%%
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Quality Control of [ 55750-05-5 ] Purity: 98.00%% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number55750-05-5
Catalog No.2A-9092125
Chinese NameCaroverine hydrochloride
SynonymsCaroverine hydrochloride; Spasmium; P 201-1; Tinnex; Spadon; Caroverine HCl
Molecular FormulaC22H28ClN3O2
Molecular Weight401.93000
Purity98.00%
Density1.11g/cm3
Boiling Point521.2ºC at 760mmHg
ApplicationCarvacine hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptors. Carvacine hydrochloride is also an antioxidant and calcium blocker with vasodilatory ef
PubChem ID10051794
SMILESCCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21.Cl
InChIInChI=1S/C22H27N3O2.ClH/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17;/h6-13H,4-5,14-16H2,1-3H3;1H
InChI KeyJRNWTJUIMRLKBV-UHFFFAOYSA-N
Hazard Symbolstransportation
BioactivityCaroverine hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus[1][2][3]. Related Catalog Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Target NMDA[1] AMPA[1] In Vitro Caroverine (1 μM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) and noradrenaline (1 μM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta[3]. In Vivo Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat[4]. Animal Model: Sprague-Dawley rats of either sex (250-300 g) received impulse noise exposure[4] Dosage: 1.44 mg/rat Administration: 20 mg/mL; s.c. 1.0 mL/h for 72 h Result: Significantly protected the cochlea against impulse noise trauma. References [1]. Chen Z, et, al. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Audiol Neurootol. Jan-Feb 2003;8(1):49-56. [2]. Denk DM, et, al. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol. 1997 Nov;117(6):825-30. [3]. Ishida Y, et, al. Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium-blocking agent. Br J Pharmacol. 1980;71(1):343-8. [4]. Duan M, et, al. Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat. Acta Otolaryngol. 2006 Dec;126(11):1140-7. Chemical & Physical Properties Density 1.11g/cm3 Boiling Point 521.2ºC at 760mmHg Molecular Formula C22H28ClN3O2 Molecular Weight 401.93000 Flash Point 269ºC Exact Mass 401.18700 PSA 47.36000 LogP 4.13970 InChIKey JRNWTJUIMRLKBV-UHFFFAOYSA-N SMILES CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21.Cl
Use ofCaroverine hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus[1][2][3]. Properties Articles23 Name 1-[2-(diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]quinoxalin-2-one,hydrochloride Synonym More Synonyms Caroverine HCl Biological Activity Description Caroverine hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus[1][2][3]. Related Catalog Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR NMDA[1] AMPA[1] References [1]. Chen Z, et, al. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Audiol Neurootol. Jan-Feb 2003;8(1):49-56. [2]. Denk DM, et, al. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol. 1997 Nov;117(6):825-30. [3]. Ishida Y, et, al. Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium-blocking agent. Br J Pharmacol. 1980;71(1):343-8. [4]. Duan M, et, al. Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat. Acta Otolaryngol. 2006 Dec;126(11):1140-7. Chemical & Physical Properties Exact Mass 401.18700 PSA 47.36000 LogP 4.13970 InChIKey JRNWTJUIMRLKBV-UHFFFAOYSA-N
Transport InfoProduct name: Purity: 96.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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