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MIANSERIN structure, CAS 24219-97-4

MIANSERIN

CAS Number24219-97-4

Synonyms[3H]-(±)-Mianserin; Org-4360; (R)-Mianserine; Org-5859; MIANSERIN; Dibenzoc,fpyrazino1,2-aazepine,1,2,3,4,10,14b-hexahydro-2-methyl; (S)-Mianserine; 2-methyl-1,2,3,4,10,14b-hexahydro-dibenzo[c,f]pyrazino[1,2-a]azepine

Molecular FormulaC18H20N2

Molecular Weight264.37

Purity

Density1.18g/cm3

Boiling Point411.3ºC at 760mmHg

Melting Point

Flash Point

Appearance

EINECS

MSDSChineseEnglish

Symbol6.1(b)

Signal WordWarning

Cat. No.: 2A-9092099 Purity:
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Quality Control of [ 24219-97-4 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number24219-97-4
Catalog No.2A-9092099
Chinese Name米安舍林
Synonyms[3H]-(±)-Mianserin; Org-4360; (R)-Mianserine; Org-5859; MIANSERIN; Dibenzoc,fpyrazino1,2-aazepine,1,2,3,4,10,14b-hexahydro-2-methyl; (S)-Mianserine; 2-methyl-1,2,3,4,10,14b-hexahydro-dibenzo[c,f]pyrazino[1,2-a]azepine
Molecular FormulaC18H20N2
Molecular Weight264.37
Density1.18g/cm3
Boiling Point411.3ºC at 760mmHg
Storage Condition2-8℃
PackagingIII
ApplicationMianserin is an H1 receptor inverse agonist.
HTC2933990090
PubChem ID5025442
MDL NumberC18H20N2
SMILESCN1CCN2c3ccccc3Cc3ccccc3C2C1
InChIInChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
InChI KeyUEQUQVLFIPOEMF-UHFFFAOYSA-N
Hazard Symbols6.1(b)
MSDSmsds/92099_1_24219_97_4.pdf
Use ofProperties Name mianserin Synonym More Synonyms Mianserin Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease References [1]. Olianas MC, et al. The atypical antidepressant mianserin exhibits agonist activity at κ-opioid receptors. Br J Pharmacol. 2012 Nov;167(6):1329-41. [2]. Roeder T. High-affinity antagonists of the locust neuronal octopamine receptor. Eur J Pharmacol. 1990 Nov 27;191(2):221-4. Chemical & Physical Properties Molecular Formula C18H20N2 Exact Mass 264.16300 PSA 6.48000 LogP 3.08680 InChIKey UEQUQVLFIPOEMF-UHFFFAOYSA-N Storage condition 2-8℃ Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl- CAS REGISTRY NUMBER : 24219-97-4 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C18-H20-N2 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - man DOSE/DURATION : TOXIC EFFECTS : Cardiac - EKG changes not diagnostic of specified effects Cardiac - other changes REFERENCE : MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914- Volume(issue)/page/year: 140,166,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Blood - agranulocytosis REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 291,1375,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : 1200 ug/kg TOXIC EFFECTS : Cardiac - arrhythmias (including changes in conduction) Cardiac - change in rate REFERENCE : HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 10,383,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 3,357,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 40,235,1983 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SEX/DURATION : female 8-20 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral REFERENCE : ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 7,504,1984 Safety Information RIDADR UN 3249 Packaging Group III Hazard Class 6.1(b) HS Code 2933990090 Synthetic Route Total: 1 Page 2-(4-Methyl-2-p... CAS#:61337-89-1 CAS#:24219-97-4 Literature: Sumitomo Chemical Company, Limited Patent: EP2135870 A1, 2009 ; Location in patent: Page/Page column 5-6 ; CAS#:21535-46-6 CAS#:24219-97-4 Literature: Hulinska, Hana; Polivka, Zdenek; Jilek, Jiri; Sindelar, Karel; Holubek, Jiri; et al. Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 8 p. 1820 - 1844 Precursor & DownStream Precursor 1 CAS#:61337-89-1 2-(4-Methyl-2-p... DownStream 4 CAS#:57257-81-5 desmethyl mianserin CAS#:71936-92-0 Desmethylmianserin CAS#:77117-73-8 8-Hydroxydesmet... CAS#:81957-76-8 Mianserin-d3
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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