CAS Number147511-69-1
SynonymsITAVASTATIN; Pitavastatin; (6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid; PITVASTATIN; MFCD04113054
Molecular FormulaC25H24FNO4
Molecular Weight421.47
Purity98%
Density1.4±0.1 g/cm3
Boiling Point692.0±55.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 147511-69-1 |
| Catalog No. | 2A-9092083 |
| Chinese Name | 匹伐他汀 |
| Synonyms | ITAVASTATIN; Pitavastatin; (6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid; PITVASTATIN; MFCD04113054 |
| Molecular Formula | C25H24FNO4 |
| Molecular Weight | 421.47 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 692.0±55.0 °C at 760 mmHg |
| Storage Condition | 2-8℃ |
| Application | Pitavastatin (NK-104) is an HMG-CoA reductase inhibitor that inhibits the synthesis of acetate to cholesterol with an IC50 of 5.8 nM. |
| HTC | 3004909090 |
| PubChem ID | 14807037 |
| MDL Number | C25H24FNO4 |
| SMILES | O=C(O)CC(O)CC(O)C=Cc1c(C2CC2)nc2ccccc2c1-c1ccc(F)cc1.[Ca+2] |
| InChI | InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/b12-11+ |
| InChI Key | VSQHXQMFUCHGBD-NRFPMOEYSA-N |
| MSDS | msds/92083_1_147511_69_1.pdf |
| Use of | Properties Name pitavastatin Synonym More Synonyms Pitavastatin Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Research Areas >> Cardiovascular Disease References [1]. Morikawa S, et al. Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells. J Atheroscler Thromb. 2000;7(3):138-44. [2]. Katsuki S, et al. Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes. Circulation. 2014 Feb 25;129(8):896-906. [3]. Tajiri K, et al. Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice. Cardiovasc Drugs Ther. 2013 Oct;27(5):413-24. [4]. Hamano T, et al. Pitavastatin decreases tau levels via the inactivation of Rho/ROCK. Neurobiol Aging. 2012 Oct;33(10):2306-20. Chemical & Physical Properties Molecular Formula C25H24FNO4 Exact Mass 421.168945 PSA 90.65000 Index of Refraction 1.680 InChIKey VSQHXQMFUCHGBD-NRFPMOEYSA-N Storage condition 2-8℃ Safety Information Hazard Codes Xi HS Code 3004909090 |
| Transport Info | Product Name: Pitavastatin |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| Epi Lovastatin | 79952-44-6 | 2A-9091933 |
| 2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-diMethoxybenzoic Acid (Donepezil IMpurity) | 197010-25-6 | 2A-9091943 |
| rac-Naproxen 2-Propyl Ester | 68641-85-0 | 2A-9091947 |
| Doxorubicinolone | 56149-23-9 | 2A-9092023 |
| Dalbavancin | 17-1500-79-1 | 2A-9092077 |
| Ribavirin BP | 2A-173801 | 2A-9092117 |
| (S)-AMISULPRIDE | 71675-92-8 | 2A-9092131 |
| Formoterol fumarate dihydrate | 183814-30-4 | 2A-9092167 |
| VERAPAMIL HYDROCHLORIDE | 23313-68-0 | 2A-9092196 |
| GEMIFLOXACIN MESYLATE | 214346-13-1 | 2A-9092206 |
| Browse all API & Advanced Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS