CAS Number165800-06-6
Synonyms(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid,hydrate; Zoledronic acid monohydrate; Reclast; Zometa; [1-Hydroxy-2-(1H-imidazol-1-yl)-1,1-ethanediyl]bis(phosphonic acid) hydrate (1:1); Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, hydrate (1:1); (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid hydrate; MFCD08448695; Aclasta; 1-Hydroxy-2-(1-imidazolyl)ethane-1,1-diphosphonic Acid Monohydrate; [1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) hydrate (1:1); Zoledronic acid hydrate; Zoledronic acid; Zoledronic acid (monohydrate)
Molecular FormulaC5H12N2O8P2
Molecular Weight290.11
Purity98%
Boiling Point764ºC at 760 mmHg
Melting Point245 °C(dec.)
AppearanceWhite to off-white powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 165800-06-6 |
| Catalog No. | 2A-9092034 |
| Chinese Name | 唑来磷酸 |
| Synonyms | (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid,hydrate; Zoledronic acid monohydrate; Reclast; Zometa; [1-Hydroxy-2-(1H-imidazol-1-yl)-1,1-ethanediyl]bis(phosphonic acid) hydrate (1:1); Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, hydrate (1:1); (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid hydrate; MFCD08448695; Aclasta; 1-Hydroxy-2-(1-imidazolyl)ethane-1,1-diphosphonic Acid Monohydrate; [1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) hydrate (1:1); Zoledronic acid hydrate; Zoledronic acid; Zoledronic acid (monohydrate) |
| Molecular Formula | C5H12N2O8P2 |
| Molecular Weight | 290.11 |
| Purity | 98 |
| Boiling Point | 764ºC at 760 mmHg |
| Melting Point | 245 °C(dec.) |
| Appearance | White to off-white powder |
| Water Solubility | Water solubility: virtually insoluble; water solub |
| Storage Condition | 2-8°C |
| Application | Zoledronic acid monohydrate is a third-generation nitrogen-containing diphosphate that can inhibit osteoclast-mediated bone resorption and has anti-tumor activity. |
| HTC | 2933290090 |
| PubChem ID | 7849030 |
| MDL Number | C5H12N2O8P2 |
| SMILES | O.O=P(O)(O)C(O)(Cn1ccnc1)P(=O)(O)O |
| InChI | InChI=1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2 |
| InChI Key | FUXFIVRTGHOMSO-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/92034_1_165800_06_6.pdf |
| Bioactivity | Zoledronic acid monohydrate is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer In Vitro Zoledronic acid monohydrate induces apoptosis in HGF and HaCaT cells at 0.5 μM, and causes cell death at 1-5 μM[1]. Zoledronic Acid (50, 100 μM) causes dose- and time-dependent apoptosis in CNE-2Z cells after treatment for 24, 48, and 72 h. Zoledronic Acid (50 μM) also increases the level of ROS, which is supposed to mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chloride currents induced by Zoledronic Acid can be blocked by knocking down ClC-3 protein expression[2]. References [1]. Scheper M, et al. A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis. ibrogenesis Tissue Repair. 2010 Apr 1;3:6. [2]. Wang L, et al. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation. Clin Exp Pharmacol Physiol. 2018 Jun 8. Chemical & Physical Properties Boiling Point 764ºC at 760 mmHg Melting Point 245 °C(dec.) Molecular Formula C5H12N2O8P2 Molecular Weight 290.105 Flash Point 415.8ºC Exact Mass 290.006897 PSA 181.96000 Vapour Pressure 1.53E-24mmHg at 25°C InChIKey FUXFIVRTGHOMSO-UHFFFAOYSA-N SMILES O.O=P(O)(O)C(O)(Cn1ccnc1)P(=O)(O)O Storage condition 2-8°C |
| Use of | Zoledronic acid monohydrate is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity. Properties Name Zoledronic acid hydrate Synonym More Synonyms Zoledronic acid hydrate Biological Activity Description Zoledronic acid monohydrate is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer In Vitro Zoledronic acid monohydrate induces apoptosis in HGF and HaCaT cells at 0.5 μM, and causes cell death at 1-5 μM[1]. Zoledronic Acid (50, 100 μM) causes dose- and time-dependent apoptosis in CNE-2Z cells after treatment for 24, 48, and 72 h. Zoledronic Acid (50 μM) also increases the level of ROS, which is supposed to mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chloride currents induced by Zoledronic Acid can be blocked by knocking down ClC-3 protein expression[2]. References [1]. Scheper M, et al. A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis. ibrogenesis Tissue Repair. 2010 Apr 1;3:6. [2]. Wang L, et al. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation. Clin Exp Pharmacol Physiol. 2018 Jun 8. Chemical & Physical Properties Molecular Formula C5H12N2O8P2 Exact Mass 290.006897 PSA 181.96000 InChIKey FUXFIVRTGHOMSO-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
| Related Products in LED & Optoelectronic Materials | ||
|---|---|---|
| 1-Methyl-hexahydropyrrolo[3,4-b]pyrroleDihydrochloride | 1197193-27-3 | 2A-9087181 |
| 5-Methyl-1H-hexahydropyrrolo[3,4-b]pyrroleDihydrochloride | 1197193-15-9 | 2A-9087185 |
| (3aS,6aS)-1-Methyl-hexahydropyrrolo[3,4-b]pyrroleDihydrochloride | 1234805-59-4 | 2A-9087194 |
| 4-(Aminoethyl)thiazoleDihydrochloride | 7771-09-7 | 2A-9087538 |
| "3,6-Dichloro-9-(Oxiran-2-ylmethy l)-9H-Carbazole " | 65679-71-2 | 2A-9090793 |
| 1-broMo-9H-carbazole | 16807-11-7 | 2A-9092814 |
| 4-BroMo-9H-carbazole | 3652-89-9 | 2A-9092815 |
| 3-broMo-6,9-diphenyl-9H-carbazole | 1160294-85-8 | 2A-9092816 |
| 1,1'-(9-ETHYL-9H-CARBAZOLE-3,6-DIYL)DIETHANONE | 1483-97-2 | 2A-0102568 |
| 1,2,3,4-TETRAHYDRO-4-OXACARBAZOLE | 98166-25-7 | 2A-0102734 |
| Browse all LED & Optoelectronic Materials products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS