| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1139-83-9 |
| Catalog No. | 2A-9092004 |
| Chinese Name | 尿石素B |
| Synonyms | urolithin-B |
| Molecular Formula | C13H8O3 |
| Molecular Weight | 212.20 |
| Purity | ≥95 (HPLC) |
| Density | 1.395g/cm3 |
| Boiling Point | 432.6ºC at 760 mmHg |
| Appearance | powder |
| Storage Condition | 2-8°C, store in inert gas |
| Application | Urolithin B is one of the intestinal microbial metabolites of ellagitannins and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and d |
| HTC | 2914400090 |
| PubChem ID | 329825989 |
| MDL Number | MFCD00034338 |
| SMILES | [o]1c2c(c3c([c]1=O)cccc3)ccc(c2)O |
| InChI | 1S/C13H8O3/c14-8-5-6-10-9-3-1-2-4-11(9)13(15)16-12(10)7-8/h1-7,14H |
| InChI Key | WXUQMTRHPNOXBV-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/92004_1_1139_83_9.pdf |
| Bioactivity | Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass[1][2]. Related Catalog Signaling Pathways >> Epigenetics >> AMPK Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> MAPK/ERK Pathway >> JNK Signaling Pathways >> Stem Cell/Wnt >> ERK References [1]. Lee G, et al. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 2019 Mar 1;55:50-57. [2]. Rodriguez J, et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):583-597. Chemical & Physical Properties Density 1.395g/cm3 Boiling Point 432.6ºC at 760 mmHg Molecular Formula C13H8O3 Molecular Weight 212.20100 Flash Point 196.6ºC Exact Mass 212.04700 PSA 50.44000 LogP 2.65180 Vapour Pressure 4.34E-08mmHg at 25°C Index of Refraction 1.679 InChIKey WXUQMTRHPNOXBV-UHFFFAOYSA-N SMILES O=c1oc2cc(O)ccc2c2ccccc12 |
| Use of | Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass[1][2]. Properties Name 3-hydroxybenzo[c]chromen-6-one Synonym More Synonyms Urolithin B Biological Activity Description Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass[1][2]. Related Catalog Signaling Pathways >> Epigenetics >> AMPK Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> MAPK/ERK Pathway >> JNK Signaling Pathways >> Stem Cell/Wnt >> ERK References [1]. Lee G, et al. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 2019 Mar 1;55:50-57. [2]. Rodriguez J, et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):583-597. Chemical & Physical Properties Molecular Formula C13H8O3 Exact Mass 212.04700 PSA 50.44000 LogP 2.65180 Index of Refraction 1.679 InChIKey WXUQMTRHPNOXBV-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available If applicable, the chemical meets the requirements of the Regulations on the Safety Management of Hazardous Chemicals (adopted by the State Council on January 9, 2002). |
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