CAS Number2079-89-2
SynonymsPropionitrile, 3-amino-, fumarate (2:1); 2-Cyanoethanaminium hydrogen (2E)-but-2-enedioate (1:1:1); 2-aminopropionitril fumarate; 3-Aminopropanenitrile (2E)-but-2-enedioate (1:1); Propanenitrile, 3-amino-, (2E)-2-butenedioate (1:1); EINECS 218-208-7; bis(3-aminopropiononitrile) fumarate; 3-Aminopropionitrile, fumarate; Propionitrile, 3-amino-, fumarate; B-aminopropionitrile; 3-Aminopionitrile Fumarate; Propionitrile, 3-amino-, fumarate (1:1); 3-Aminopropionitrile fumarate salt; di(2-cyanoethylammonium) fumarate; β-Aminopropionitrile, fumarate; 2-Cyanoethylamine hemifumarate; MFCD00078321; Propanenitrile, 3-amino-, (E)-2-butenedioate (1:1); 3-Aminopropionitrile fumarate; B-aminopropionitrile fumarate; B-aminopropionitrile monofumarate; 3-amino-propionitrilfumarate(2:1); 3-Aminopropanenitril
Molecular FormulaNH2CH2CH2CN · ½ (HO2CCH=CHCO2H)
Molecular Weight128.13
Purity≥98 (TLC)%
Boiling Point355.5ºC at 760 mmHg
Melting Point177 °C (dec.) (lit.)
Appearancepowder
EINECS218-208-7
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2079-89-2 |
| Catalog No. | 2A-9091653 |
| Chinese Name | 3-延胡素酸氨基丙腈酯 |
| Synonyms | Propionitrile, 3-amino-, fumarate (2:1); 2-Cyanoethanaminium hydrogen (2E)-but-2-enedioate (1:1:1); 2-aminopropionitril fumarate; 3-Aminopropanenitrile (2E)-but-2-enedioate (1:1); Propanenitrile, 3-amino-, (2E)-2-butenedioate (1:1); EINECS 218-208-7; bis(3-aminopropiononitrile) fumarate; 3-Aminopropionitrile, fumarate; Propionitrile, 3-amino-, fumarate; B-aminopropionitrile; 3-Aminopionitrile Fumarate; Propionitrile, 3-amino-, fumarate (1:1); 3-Aminopropionitrile fumarate salt; di(2-cyanoethylammonium) fumarate; β-Aminopropionitrile, fumarate; 2-Cyanoethylamine hemifumarate; MFCD00078321; Propanenitrile, 3-amino-, (E)-2-butenedioate (1:1); 3-Aminopropionitrile fumarate; B-aminopropionitrile fumarate; B-aminopropionitrile monofumarate; 3-amino-propionitrilfumarate(2:1); 3-Aminopropanenitril |
| Molecular Formula | NH2CH2CH2CN · ½ (HO2CCH=CHCO2H) |
| Molecular Weight | 128.13 |
| Purity | ≥98 (TLC) |
| Boiling Point | 355.5ºC at 760 mmHg |
| Melting Point | 177 °C (dec.) (lit.) |
| Appearance | powder |
| Storage Condition | 1. This product should be kept sealed. |
| Application | 3-Aminopropionitrile fumarate (2:1) is an amycin that inhibits the cross-linking of collagen. |
| EINECS | 218-208-7 |
| HTC | 2926909090 |
| PubChem ID | 24278224 |
| MDL Number | MFCD00013142 |
| SMILES | NCCC#N.NCCC#N.OC(=O)\C=C\C(O)=O |
| InChI | 1S/C4H4O4.2C3H6N2/c5-3(6)1-2-4(7)8;2*4-2-1-3-5/h1-2H,(H,5,6)(H,7,8);2*1-2,4H2/b2-1+;; |
| InChI Key | NYMXYZMHOZAPHQ-SEPHDYHBSA-N |
| Beilstein/REAXYS | 3573532 |
| NACRES Code | NA.77 |
| UNSPSC | 12352202 |
| MSDS | msds/91653_1_2079_89_2.pdf |
| Bioactivity | 3-Aminopropionitrile fumarate (2:1) is a lathyrogen which inhibits crosslinking of collagen. Related Catalog Signaling Pathways >> Others >> Others Target Collagen[1]. In Vivo Twenty days after the induction of tendinitis, intralesional treatment with 3-Aminopropionitrile fumarate (2:1) (BAPN-F) is performed and the contralateral limbs receive saline. A biopsy is obtained and gross and histopathological analysis is performed on the 150 th day of the experiment. The collagen fibrillar alignment pattern in the healing area is better in the 3-Aminopropionitrile fumarate (2:1) group submitted to controlled exercise than in the other group, as observed by sonographic and histopathologic examination. The present results indicate that 3-Aminopropionitrile fumarate (2:1) in combination with controlled loading improved scar remodeling and tendon wound collagen maturation[1]. Animal Admin Horses[1] Seven female and nine male horses are assigned at random to two groups (G1 and G2) submitted to different treatments after the induction of acute tendinitis. Each group consists of eight animals injected with type 1 collagenase, 1 mL, 2.5 mg/mL, in the middle metacarpal third into the superficial digital flexor tendons of both forelimbs. Twenty days after the injection of collagenase, one of the limbs (G1A/G2A) receives an injection of 3-Aminopropionitrile fumarate (2:1), 3 mL, 0.8 mg/mL, and the other limb (G1B) receives the same volume of buffered saline as control. Group one was left in box rest, and group two was submitted to controlled exercise during the experiment[1]. References [1]. A.L.G. Alves, et al. Effects of beta-aminopropionitrile fumarate and exercise on equine tendon healing: gross and histological aspects. Journal of Equine Veterinary Science, 2001, 21 (7) :335-340. Chemical & Physical Properties Boiling Point 355.5ºC at 760 mmHg Melting Point 177 °C (dec.)(lit.) Molecular Formula C7H10N2O4 Molecular Weight 186.165 Flash Point 183ºC Exact Mass 186.064056 PSA 124.41000 LogP 0.27088 Vapour Pressure 5.19E-06mmHg at 25°C InChIKey NYMXYZMHOZAPHQ-SEPHDYHBSA-N SMILES N#CCCN.N#CCCN.O=C(O)C=CC(=O)O Storage condition -20°C |
| Use of | 3-Aminopropionitrile fumarate (2:1) is a lathyrogen which inhibits crosslinking of collagen. Properties Articles28 Name 3-aminopropionitrile fumarate Synonym More Synonyms 3-aminopropionitrile fumarate Biological Activity Description 3-Aminopropionitrile fumarate (2:1) is a lathyrogen which inhibits crosslinking of collagen. Related Catalog Signaling Pathways >> Others >> Others Collagen[1]. In Vivo Twenty days after the induction of tendinitis, intralesional treatment with 3-Aminopropionitrile fumarate (2:1) (BAPN-F) is performed and the contralateral limbs receive saline. A biopsy is obtained and gross and histopathological analysis is performed on the 150 th day of the experiment. The collagen fibrillar alignment pattern in the healing area is better in the 3-Aminopropionitrile fumarate (2:1) group submitted to controlled exercise than in the other group, as observed by sonographic and histopathologic examination. The present results indicate that 3-Aminopropionitrile fumarate (2:1) in combination with controlled loading improved scar remodeling and tendon wound collagen maturation[1]. References [1]. A.L.G. Alves, et al. Effects of beta-aminopropionitrile fumarate and exercise on equine tendon healing: gross and histological aspects. Journal of Equine Veterinary Science, 2001, 21 (7) :335-340. Chemical & Physical Properties Molecular Formula C7H10N2O4 Exact Mass 186.064056 PSA 124.41000 LogP 0.27088 InChIKey NYMXYZMHOZAPHQ-SEPHDYHBSA-N SMILES N#CCCN.N#CCCN.O=C(O)C=CC(=O)O |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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