CAS Number134-64-5
SynonymsLobeline sulfate; EINECS 205-151-8; MFCD00135592; 2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone,sulfuric acid
Molecular FormulaC44H56N2O8S
Molecular Weight772.98900
Purity98%
Density1.085g/cm3
Boiling Point485.6ºC at 760mmHg
Melting Point152-154 °C
Appearancewhite powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 134-64-5 |
| Catalog No. | 2A-9091470 |
| Chinese Name | 硫酸洛贝林 |
| Synonyms | Lobeline sulfate; EINECS 205-151-8; MFCD00135592; 2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone,sulfuric acid |
| Molecular Formula | C44H56N2O8S |
| Molecular Weight | 772.98900 |
| Purity | 98 |
| Density | 1.085g/cm3 |
| Boiling Point | 485.6ºC at 760mmHg |
| Melting Point | 152-154 °C |
| Appearance | white powder |
| Packaging | III |
| Application | Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) is a non-stimulant agent that alters dopamine uptake in the brain. Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) inhibits nicotine |
| HTC | 2933399090 |
| SMILES | CN1C(CC(=O)c2ccccc2)CCCC1CC(O)c1ccccc1.O=S(=O)(O)O |
| InChI | InChI=1S/2C22H27NO2.H2O4S/c2*1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18;1-5(2,3)4/h2*2-7,9-12,19-21,24H,8,13-16H2,1H3;(H2,1,2,3,4)/t2*19-,20+,21-;/m00./s1 |
| InChI Key | BEDBXOIWRNCGAU-NFQNBQCWSA-N |
| Hazard Symbols | 6.1 |
| Bioactivity | Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) is a nonstimulant medication that can alter dopamine uptake in brain. Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) inhibits nicotine-induced hyperactivity and is effective in smoking cessation[1][2]. Related Catalog Research Areas >> Neurological Disease Target IC50: endogenous metabolite[1] References [1]. Robert J. Laffan, et al.EMETIC ACTION OF NICOTINE AND LOBELINE. Journal of Pharmacology and Experimental Therapeutics December 1957, 121 (4) 468-476 [2]. https://mayoclinic.pure.elsevier.com/en/publications/a-smoking-cessation-trial-with-lobeline-sulfate-a-pilot-st Chemical & Physical Properties Density 1.085g/cm3 Boiling Point 485.6ºC at 760mmHg Melting Point 152-154 °C Molecular Formula C44H56N2O8S Molecular Weight 772.98900 Flash Point 247.5ºC Exact Mass 772.37600 PSA 164.06000 LogP 8.77580 Vapour Pressure 3.05E-10mmHg at 25°C InChIKey BEDBXOIWRNCGAU-NFQNBQCWSA-N SMILES CN1C(CC(=O)c2ccccc2)CCCC1CC(O)c1ccccc1.O=S(=O)(O)O |
| Use of | Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) is a nonstimulant medication that can alter dopamine uptake in brain. Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) inhibits nicotine-induced hyperactivity and is effective in smoking cessation[1][2]. Properties Name lobeline sulfate Synonym More Synonyms Lobeline sulfate Biological Activity Description Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) is a nonstimulant medication that can alter dopamine uptake in brain. Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) inhibits nicotine-induced hyperactivity and is effective in smoking cessation[1][2]. Related Catalog Research Areas >> Neurological Disease IC50: endogenous metabolite[1] References [1]. Robert J. Laffan, et al.EMETIC ACTION OF NICOTINE AND LOBELINE. Journal of Pharmacology and Experimental Therapeutics December 1957, 121 (4) 468-476 [2]. https://mayoclinic.pure.elsevier.com/en/publications/a-smoking-cessation-trial-with-lobeline-sulfate-a-pilot-st Chemical & Physical Properties Molecular Formula C44H56N2O8S Exact Mass 772.37600 PSA 164.06000 LogP 8.77580 InChIKey BEDBXOIWRNCGAU-NFQNBQCWSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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