CAS Number156223-05-1
Synonyms3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl; 3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine dihydrochloride; 3-(2,4-dimethoxybenzylidene)anabaseine; 3-(2,4-Dimethoxybenzyl)-3,4,5,6-tetrahydro-2,3'-bipyridine; (3E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine; 3-(2,4)-DiMethoxybenzylidineanabaseine; GTS-21; DMXB-A; GTS 21 2HCl; GTS-21 (dihydrochloride)
Molecular FormulaC19H20O2N2
Molecular Weight308.38
Density1.1±0.1 g/cm3
Boiling Point485.6±45.0 °C at 760 mmHg
Melting Point216-217℃ (decomposition)
Appearancepowder,faint yellow to dark yellow
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 156223-05-1 |
| Catalog No. | 2A-9091180 |
| Chinese Name | GTS-21二盐酸盐(DMBX-A) |
| Synonyms | 3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl; 3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine dihydrochloride; 3-(2,4-dimethoxybenzylidene)anabaseine; 3-(2,4-Dimethoxybenzyl)-3,4,5,6-tetrahydro-2,3'-bipyridine; (3E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine; 3-(2,4)-DiMethoxybenzylidineanabaseine; GTS-21; DMXB-A; GTS 21 2HCl; GTS-21 (dihydrochloride) |
| Molecular Formula | C19H20O2N2 |
| Molecular Weight | 308.38 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 485.6±45.0 °C at 760 mmHg |
| Melting Point | 216-217℃ (decomposition) |
| Appearance | powder,faint yellow to dark yellow |
| Water Solubility | H2O: >5mg/mL |
| Storage Condition | 2-8°C |
| Application | GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor (α7nAChR) agonist. |
| HTC | 2933399090 |
| PubChem ID | 58093549 |
| MDL Number | MFCD05237234 |
| SMILES | COc1ccc(C=C2CCCN=C2c2cccnc2)c(OC)c1.Cl.Cl |
| InChI | InChI=1S/C19H20N2O2.ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;/h3,6-9,11-13H,4-5,10H2,1-2H3;1H/b15-11+; |
| InChI Key | BXKYFUGAAFLYJL-UHFFFAOYSA-N |
| MSDS | msds/91180_1_156223_05_1.pdf |
| Use of | Properties Articles28 Name 3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl Synonym More Synonyms GTS-21 Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Inflammation/Immunology References [1]. Yue Y, et al. GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-κB signaling pathway through the α7 nicotinic acetylcholine receptor. Int Immunopharmacol. 2015 Dec;29(2):504-12. [2]. Nullens S, et al. EFFECT OF GTS-21, AN ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST, ON CLP-INDUCED INFLAMMATORY, GASTROINTESTINAL MOTILITY, AND COLONIC PERMEABILITY CHANGES IN MICE. Shock. 2016 Apr;45(4):450-9. Chemical & Physical Properties PSA 43.71000 Appearance of Characters powder,faint yellow to dark yellow Index of Refraction 1.580 InChIKey BXKYFUGAAFLYJL-UHFFFAOYSA-N Safety Information RIDADR NONH for all modes of transport WGK Germany 3 RTECS DW1764860 HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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