CAS Number313516-66-4
Synonyms2-Chloro-5-nitro-N-4-pyridinyl-benzamide Benzamide,2-chloro-5-nitro-N-4-pyridinyl; Benzamide,2-chloro-5-nitro-N-4-pyridinyl; 2-chloro-5-nitro-N-pyridin-4-yl-benzamide; 2-Chloro-5-nitro-N-(4-pyridinyl)benzamide; 2-Chloro-5-nitro-N-4-pyridinylbenzamide; 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide; T0070907
Molecular FormulaC12H8ClN3O3
Molecular Weight277.66
Purity≥98 (HPLC)%
Density1.5±0.1 g/cm3
Boiling Point381.7±37.0 °C at 760 mmHg
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 313516-66-4 |
| Catalog No. | 2A-9091067 |
| Chinese Name | T0070907 |
| Synonyms | 2-Chloro-5-nitro-N-4-pyridinyl-benzamide Benzamide,2-chloro-5-nitro-N-4-pyridinyl; Benzamide,2-chloro-5-nitro-N-4-pyridinyl; 2-chloro-5-nitro-N-pyridin-4-yl-benzamide; 2-Chloro-5-nitro-N-(4-pyridinyl)benzamide; 2-Chloro-5-nitro-N-4-pyridinylbenzamide; 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide; T0070907 |
| Molecular Formula | C12H8ClN3O3 |
| Molecular Weight | 277.66 |
| Purity | ≥98 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 381.7±37.0 °C at 760 mmHg |
| Appearance | powder |
| Water Solubility | DMSO: >10mg/mL | Soluble in DMSO at 10mg/ml. Insol |
| Storage Condition | Store at RT |
| Application | T0070907 is a potent PPARγ antagonist with a Ki value of 1 nM. |
| HTC | 2933399090 |
| PubChem ID | 329826884 |
| MDL Number | MFCD00121849 |
| SMILES | [O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc2ccncc2 |
| InChI | 1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17) |
| InChI Key | FRPJSHKMZHWJBE-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352203 |
| Hazard Symbols | transportation |
| MSDS | msds/91067_1_313516_66_4.pdf |
| Bioactivity | T0070907 is a potent PPARγ antagonist with a Ki of 1 nM. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Signaling Pathways >> Cell Cycle/DNA Damage >> RAD51 Research Areas >> Cancer Target PPARγ:1 nM (Ki) PPARδ:1.8 μM (Ki) PPARα:0.85 μM (Ki) In Vitro T0070907 (50 μM) pre-treatment impairs repair of IR-induced DNA DSBs in both ME-180 and SiHa cells treated with irradiated (4 Gy). T0070907 (0-50 μM) significantly decreases the levels of DNA-PKcs and RAD51 proteins in ME-180 and SiHa cells[1]. T0070907 (50 μM) treatment reduces the levels of α- and β-tubulin protein in a time-dependent manner, decreases the synthesis of DNA, and prevents the radiation-induced alterations in the cell cycle regulatory proteins of ME180 and SiHa cells[2]. T0070907 (10 µM) has cytotoxicity in an adipocyte-specific and PPARγ-independent manner. T0070907 increases oxidative stress in immature adipocytes[3]. T0070907 (1 μM) blocks the induction of adipogenesis by various treatments of the adipogenic cell line 3T3-L1. T0070907 covalently modifies PPAR on cysteine 313 in helix 3 of human PPAR 2[4]. Kinase Assay To determine the binding affinity of T0070907 to the PPARs, scintillation proximity assay (SPA) is performed with the following modifications. A 90 μL reaction contains SPA buffer (10 mM K2HPO4, 10 mM KH2PO4, 2 mM EDTA, 50 mM NaCl, 1 mM dithiothreitol, 2 mM CHAPS, 10% (v/v) glycerol, pH 7.1), 50 ng of GST-PPAR (or 150 ng of GST-PPAR), 5 nM 3H-labeled radioligands, and 5 μL of T0070907 in Me2SO. After incubation for 1 h at room temperature, 10 μL of polylysine-coated SPA beads (at 20 mg/mL in SPA buffer) are added, and the mixture is incubated for 1 h before reading in Packard Topcount. [3H]Rosiglitazone is used for PPAR, and [3H]GW2433 is used for PPAR and PPAR. References [1]. An Z, et al. T0070907 inhibits repair of radiation-induced DNA damage by targeting RAD51. Toxicol In Vitro. 2016 Dec;37:1-8 [2]. An Z, et al. T0070907, a PPAR γ inhibitor, induced G2/M arrest enhances the effect of radiation in human cervical cancer cells through mitotic catastrophe. Reprod Sci. 2014 Nov;21(11):1352-61. [3]. Kawahara A, et al. Peroxisome proliferator-activated receptor γ (PPARγ)-independent specific cytotoxicity against immature adipocytes induced by PPARγ antagonist T0070907. Biol Pharm Bull. 2013;36(9):1428-34 [4]. Lee G, et al. T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem. 2002 May 31;277(22):19649-57. Epub 2002 Mar 4 Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 381.7±37.0 °C at 760 mmHg Molecular Formula C12H8ClN3O3 Molecular Weight 277.663 Flash Point 184.6±26.5 °C Exact Mass 277.025421 PSA 87.81000 LogP 2.25 Appearance of Characters white Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.684 Storage condition Store at RT Water Solubility DMSO: >10mg/mL | Soluble in DMSO at 10mg/ml. Insoluble in water. |
| Use of | T0070907 is a potent PPARγ antagonist with a Ki of 1 nM. Properties Articles12 Name 2-chloro-5-nitro-N-pyridin-4-ylbenzamide Synonym More Synonyms T0070907 Biological Activity Description T0070907 is a potent PPARγ antagonist with a Ki of 1 nM. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Signaling Pathways >> Cell Cycle/DNA Damage >> RAD51 Research Areas >> Cancer PPARγ:1 nM (Ki) PPARδ:1.8 μM (Ki) PPARα:0.85 μM (Ki) References [1]. An Z, et al. T0070907 inhibits repair of radiation-induced DNA damage by targeting RAD51. Toxicol In Vitro. 2016 Dec;37:1-8 [3]. Kawahara A, et al. Peroxisome proliferator-activated receptor γ (PPARγ)-independent specific cytotoxicity against immature adipocytes induced by PPARγ antagonist T0070907. Biol Pharm Bull. 2013;36(9):1428-34 [4]. Lee G, et al. T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem. 2002 May 31;277(22):19649-57. Epub 2002 Mar 4 Chemical & Physical Properties Exact Mass 277.025421 PSA 87.81000 Appearance of Characters white Index of Refraction 1.684 Storage condition Store at RT |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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