CAS Number13463-41-7
SynonymsZinc pyrithione; 1-Hydroxypyridine-2-thione zinc salt; MFCD00067336; EINECS 236-671-3; 2-Pyridinethiol 1-Oxide Zinc Salt; Bis(2-pyridylthio) Zinc 1,1'-Dioxide
Molecular FormulaC10H8N2O2S2Zn
Molecular Weight317.70
Purity≥95%
Density1.782 g/cm3 (25ºC)
Boiling Point253.8ºC at 760 mmHg
Melting Point262ºC
AppearanceOff-white to yellow-brown powder
EINECS236-671-3
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 13463-41-7 |
| Catalog No. | 2A-9008916 |
| Chinese Name | 吡啶硫酮锌 |
| Synonyms | Zinc pyrithione; 1-Hydroxypyridine-2-thione zinc salt; MFCD00067336; EINECS 236-671-3; 2-Pyridinethiol 1-Oxide Zinc Salt; Bis(2-pyridylthio) Zinc 1,1'-Dioxide |
| Molecular Formula | C10H8N2O2S2Zn |
| Molecular Weight | 317.70 |
| Purity | ≥95 |
| Density | 1.782 g/cm3 (25ºC) |
| Boiling Point | 253.8ºC at 760 mmHg |
| Melting Point | 262ºC |
| Appearance | Off-white to yellow-brown powder |
| Water Solubility | Insoluble ( |
| Storage Condition | Store in a cool, dry place. |
| Packaging | III |
| Application | Zinc Pyrithione is antifungal and bacterial, disrupting membrane transport by blocking proton pumps. |
| EINECS | 236-671-3 |
| HTC | 2933399010 |
| UN(IATA) | UN 2811 |
| PubChem ID | 57654263 |
| MDL Number | MFCD00067336 |
| SMILES | O1N2C=CC=CC2=[S][Zn]13ON4C=CC=CC4=[S]3 |
| InChI | 1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2 |
| InChI Key | OTPSWLRZXRHDNX-UHFFFAOYSA-L |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | 6.1(b) |
| Risk Codes | R24/25-26-37/38-41 |
| Safety Description | S26-28-36/37/39-45 |
| MSDS | msds/8916_1_13463_41_7.pdf |
| Bioactivity | Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.Target: Proton PumpZinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM [1]. Zinc pyrithione is an unusual synthetic potentiator that potently activates both heterologous and native M channels by inducing channel opening at the resting potential [2]. Zinc pyrithione rapidly accumulated in the tissues of the exposed mussels, proportionately to both exposure concentration and time. Even though the 7-d median lethal concentration (LC50) = 8.27 μM established here appears high with respect to reported ZnPT environmental concentrations, the results indicate that this biocide could represent a threat for marine organisms in coastal environments and that further investigations on its biological effects at sublethal doses are needed [3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump Research Areas >> Cardiovascular Disease References [1]. Ermolayeva, E. and D. Sanders, Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa. Appl Environ Microbiol, 1995. 61(9): p. 3385-90. [2]. Xiong, Q., H. Sun, and M. Li, Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol, 2007. 3(5): p. 287-96. [3]. Marcheselli, M., C. Rustichelli, and M. Mauri, Novel antifouling agent zinc pyrithione: determination, acute toxicity, and bioaccumulation in marine mussels (Mytilus galloprovincialis). Environ Toxicol Chem, 2010. 29(11): p. 2583-92. Chemical & Physical Properties Density 1.782 g/cm3 (25ºC) Boiling Point 253.8ºC at 760 mmHg Melting Point 262ºC Molecular Formula C10H8N2O2S2Zn Molecular Weight 317.722 Flash Point 107.3ºC Exact Mass 315.931854 PSA 101.52000 LogP 3.34050 Vapour Pressure 0.00275mmHg at 25°C InChIKey OTPSWLRZXRHDNX-UHFFFAOYSA-L SMILES [O-][n+]1ccccc1[S-].[O-][n+]1ccccc1[S-].[Zn+2] Water Solubility Insoluble ( |
| Use of | Properties Articles29 Name zinc pyrithione Synonym More Synonyms Zinc Pyrithione Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump Research Areas >> Cardiovascular Disease References [1]. Ermolayeva, E. and D. Sanders, Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa. Appl Environ Microbiol, 1995. 61(9): p. 3385-90. [2]. Xiong, Q., H. Sun, and M. Li, Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol, 2007. 3(5): p. 287-96. [3]. Marcheselli, M., C. Rustichelli, and M. Mauri, Novel antifouling agent zinc pyrithione: determination, acute toxicity, and bioaccumulation in marine mussels (Mytilus galloprovincialis). Environ Toxicol Chem, 2010. 29(11): p. 2583-92. Chemical & Physical Properties Molecular Formula C10H8N2O2S2Zn Exact Mass 315.931854 PSA 101.52000 LogP 3.34050 InChIKey OTPSWLRZXRHDNX-UHFFFAOYSA-L Water Solubility Insoluble ( |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 United Nations number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Pyrithione zinc) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Pyrithione zinc) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Pyrithione zinc) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations International Air Transport Dangerous Regulations: No Marine Pollutants (Yes/No): Yes 14.6 Special precautions No data available |
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