CAS Number66376-36-1
Synonyms(4-Amino-1-hydroxybutane-1,1-diyl)diphosphonic acid; (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid
Molecular FormulaC4H13O7N1P2
Molecular Weight249.1
Purity98%
Density1.857 g/cm3
Boiling Point616.7ºC at 760 mmHg
Melting Point230-235ºC
AppearanceWhite crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 66376-36-1 |
| Catalog No. | 2A-9000089 |
| Chinese Name | 阿仑膦酸 |
| Synonyms | (4-Amino-1-hydroxybutane-1,1-diyl)diphosphonic acid; (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid |
| Molecular Formula | C4H13O7N1P2 |
| Molecular Weight | 249.1 |
| Purity | 98 |
| Density | 1.857 g/cm3 |
| Boiling Point | 616.7ºC at 760 mmHg |
| Melting Point | 230-235ºC |
| Appearance | White crystalline powder |
| Water Solubility | Water solubility: insoluble |
| Storage Condition | Store in a sealed container in a cool, dry place. |
| Packaging | III |
| Application | Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPs) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid has therapeutic effects on postmen |
| HTC | 2931900090 |
| MDL Number | MFCD00868112 |
| SMILES | NCCCC(O)(P(=O)(O)O)P(=O)(O)O |
| InChI | InChI=1S/C4H13NO7P2/c5-3-1-2-4(6,13(7,8)9)14(10,11)12/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12) |
| InChI Key | OGSPWJRAVKPPFI-UHFFFAOYSA-N |
| MSDS | msds/89_1_66376_36_1.pdf |
| Bioactivity | Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget's disease[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others In Vitro Bisphosphonates are widely used in the treatment of osteoporosis, and among the bisphosphonates, alendronic acid is the most frequently prescribed drug. Bisphosphonates have powerful inhibitory effects on bone remodeling, a process that is critically important for fracture healing[2]. References [1]. Teixeira S, et al. Alendronic Acid as Ionic Liquid: New Perspective on Osteosarcoma. Pharmaceutics. 2020 Mar 24;12(3). pii: E293. [2]. Duckworth AD, et al. Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial. J Bone Miner Res. 2019 Jun;34(6):1025-1032. Chemical & Physical Properties Density 1.857 g/cm3 Boiling Point 616.7ºC at 760 mmHg Melting Point 230-235ºC Molecular Formula C4H13NO7P2 Molecular Weight 249.09600 Flash Point 326.7ºC Exact Mass 249.01700 PSA 180.93000 InChIKey OGSPWJRAVKPPFI-UHFFFAOYSA-N SMILES NCCCC(O)(P(=O)(O)O)P(=O)(O)O |
| Use of | Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget's disease[1]. Properties Name alendronic acid Synonym More Synonyms Alendronic acid Biological Activity Description Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget's disease[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others In Vitro Bisphosphonates are widely used in the treatment of osteoporosis, and among the bisphosphonates, alendronic acid is the most frequently prescribed drug. Bisphosphonates have powerful inhibitory effects on bone remodeling, a process that is critically important for fracture healing[2]. References [1]. Teixeira S, et al. Alendronic Acid as Ionic Liquid: New Perspective on Osteosarcoma. Pharmaceutics. 2020 Mar 24;12(3). pii: E293. [2]. Duckworth AD, et al. Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial. J Bone Miner Res. 2019 Jun;34(6):1025-1032. Chemical & Physical Properties Molecular Formula C4H13NO7P2 Exact Mass 249.01700 PSA 180.93000 InChIKey OGSPWJRAVKPPFI-UHFFFAOYSA-N SMILES NCCCC(O)(P(=O)(O)O)P(=O)(O)O |
| Tax Rebate | 13.0% |
| Supervision | AB (Inbound cargo customs clearance form) |
| Transport Info | Product Name: Alendronate |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| (3-Bromobenzyl)-(1-phenylethyl)amine | 2A-100076 | 2A-9000076 |
| (3-Bromobenzyl)pyridin-3-ylmethylamine | 436096-90-1 | 2A-9000077 |
| (3-Chloropyridazin-6-yl)hydrazine | 17284-97-8 | 2A-9000078 |
| (3-Glycidoxypropyl)methyldiethoxysilane | 2897-60-1 | 2A-9000080 |
| (3-Glycidyloxypropyl)triethoxysilane | 2602-34-8 | 2A-9000081 |
| (4-Amino-2,3-difluorophenyl)acetic acid | 835912-66-8 | 2A-9000090 |
| (4-Amino-3-nitrophenyl)(4-fluorophenyl)methanone | 2A-100091 | 2A-9000091 |
| (4-Amino-3-nitrophenyl)phenylmethanone | 31431-19-3 | 2A-9000092 |
| (4-Amino-5-chloro-2-methoxy)-N-[3-methoxy(4-piperidyl)]benzamide | 2A-100093 | 2A-9000093 |
| (4-Benzyl-1,4-oxazinan-2-yl)methylamine | 110859-47-7 | 2A-9000094 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS