CAS Number53005-05-3
Synonymsdids; 4,4'-Diisothiocyanostilbene-2,2'-disulfonic acid; 4,4'-diisothiocyanato-stilbene-2,2'-disulfonic acid; trans-4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid; 4,4'-diisothiocyanato-2,2'-stilbenedisulfoneic acid; 4,4'-diisothiocyanostilbene-2-2'-disulphonic acid; 5-isothiocyanato-2-[(E)-2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzenesulfonic acid; 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid
Molecular FormulaC16H10N2O6S4
Molecular Weight498.48
Purity≥85 (HPLC)%
Density1.54g/cm3
Melting Point>400ºC
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 53005-05-3 |
| Catalog No. | 2A-9087759 |
| Chinese Name | 4,4′-二异硫氰酰-2,2′-基二磺酸二钠盐 |
| Synonyms | dids; 4,4'-Diisothiocyanostilbene-2,2'-disulfonic acid; 4,4'-diisothiocyanato-stilbene-2,2'-disulfonic acid; trans-4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid; 4,4'-diisothiocyanato-2,2'-stilbenedisulfoneic acid; 4,4'-diisothiocyanostilbene-2-2'-disulphonic acid; 5-isothiocyanato-2-[(E)-2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzenesulfonic acid; 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid |
| Molecular Formula | C16H10N2O6S4 |
| Molecular Weight | 498.48 |
| Purity | ≥85 (HPLC) |
| Density | 1.54g/cm3 |
| Melting Point | >400ºC |
| Appearance | solid |
| Storage Condition | Keep the container sealed and stored in a cool, dr |
| Application | DIDS is a potent RAD51 inhibitor. DIDS inhibits RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes [1][2]. |
| HTC | 2930909090 |
| MDL Number | MFCD00065493 |
| SMILES | [S](=O)(=O)(O)c1c(ccc(c1)N=C=S)\C=C\c2c(cc(cc2)N=C=S)[S](=O)(=O)O |
| InChI | 1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+ |
| InChI Key | YSCNMFDFYJUPEF-OWOJBTEDSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/87759_1_53005_05_3.pdf |
| Use of | DIDS is a potent RAD51 inhibitor. DIDS inhibits the RAD51-mediated homologous pairing and strand-exchange reactions. DIDS inhibits anion exchange and binding to the red blood cell membrane[1][2]. Properties Name 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid Synonym More Synonyms Biological Activity Description DIDS is a potent RAD51 inhibitor. DIDS inhibits the RAD51-mediated homologous pairing and strand-exchange reactions. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> RAD51 In Vitro DIDS (0-10 μM) Inhibits RAD51-mediated strand exchange[1]. DIDS (0-20 μM) inhibits DNA binding via RAD51 [1]. DIDS (10 μM; 0-60 min) stimulates the ATP hydrolyzing activity of RAD51 in the absence of DNA [1]. References [1]. Ishida T, et, al. DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange. Nucleic Acids Res. 2009 Jun;37(10):3367-76. [2]. Lepke S, et, al. stilbene-2,2'-disulfonic acid (DIDS) and its dihydro derivative (H2DIDS). J Membr Biol. 1976 Oct 20;29(1-2):147-77. Chemical & Physical Properties Molecular Formula C16H10N2O6S4 Exact Mass 453.94200 PSA 214.40000 LogP 5.98060 Index of Refraction 1.693 InChIKey YSCNMFDFYJUPEF-OWOJBTEDSA-N Safety Information HS Code 2930909090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2930909090. other organo-sulfur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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