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Synephrine hydrochloride structure, CAS 5985-28-4

Synephrine hydrochloride

CAS Number5985-28-4

SynonymsUNII:EN5D1IH09S; DL-synephrine hydrochloride; EINECS 227-804-6; Synephrine HCl; 4-(1-Hydroxy-2-(methylamino)ethyl)phenol hydrochloride; MFCD00050566; Synephrine hydrochloride; 4-[1-Hydroxy-2-(methylamino)ethyl]phenol hydrochloride (1:1); 2-methylamino-1-(4-hydroxyphenyl)-ethanol hydrochloride; Benzenemethanol, 4-hydroxy-α-[(methylamino)methyl]-, hydrochloride (1:1); (+-)-1-(4-hydroxy-phenyl)-2-methylamino-ethanol,hydrochloride; Oxedrine hydrochloride; Ocuton (TN); 1-(4-Hydroxy-phenyl)-2-methylamino-aethanol,Hydrochlorid

Molecular FormulaC9H14ClNO2

Molecular Weight203.67

Purity98%

Density

Boiling Point341.1ºC at 760 mmHg

Melting Point147-150ºC

Flash Point

AppearanceWhite fine powder

EINECS227-804-6

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9008770 Purity: 98%
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Quality Control of [ 5985-28-4 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number5985-28-4
Catalog No.2A-9008770
Chinese Name辛弗林盐酸盐
SynonymsUNII:EN5D1IH09S; DL-synephrine hydrochloride; EINECS 227-804-6; Synephrine HCl; 4-(1-Hydroxy-2-(methylamino)ethyl)phenol hydrochloride; MFCD00050566; Synephrine hydrochloride; 4-[1-Hydroxy-2-(methylamino)ethyl]phenol hydrochloride (1:1); 2-methylamino-1-(4-hydroxyphenyl)-ethanol hydrochloride; Benzenemethanol, 4-hydroxy-α-[(methylamino)methyl]-, hydrochloride (1:1); (+-)-1-(4-hydroxy-phenyl)-2-methylamino-ethanol,hydrochloride; Oxedrine hydrochloride; Ocuton (TN); 1-(4-Hydroxy-phenyl)-2-methylamino-aethanol,Hydrochlorid
Molecular FormulaC9H14ClNO2
Molecular Weight203.67
Purity98
Boiling Point341.1ºC at 760 mmHg
Melting Point147-150ºC
AppearanceWhite fine powder
Storage ConditionRefrigerator
ApplicationSynephrine (Oxedrine) hydrochloride is an alkaloid and an adrenergic receptor agonist.
EINECS227-804-6
HTC2922199090
MDL NumberC9H14ClNO2
SMILESCNCC(O)c1ccc(O)cc1.Cl
InChIInChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H
InChI KeyCOTCEGYSNTWJQV-UHFFFAOYSA-N
MSDSmsds/8770_1_5985_28_4.pdf
Use ofSynephrine Hcl(Oxedrine) is an alkaloid; synephrine produces most of its biological effects by acting as an agonist at adrenergic receptors.IC50 value:Target: adrenergic receptor agonistThere is some evidence that synephrine also has weak activity at 5-HT receptors, and that it interacts with TAAR1 (trace adrenergic amine receptors). d-synephrine inhibited the uptake of [3H]-norepinephrine with an IC50 = 5.8 μM; l-synephrine was less potent (IC50 = 13.5 μM). d-Synephrine also competitively inhibited the binding of nisoxetine[m] to rat brain cortical slices, with a Ki = 4.5 μM; l-synephrine was less potent (Ki = 8.2 μM). In experiments on the release of [3H]-norepinephrine from rat brain cortical slices, however, the l-isomer of synephrine was a more potent enhancer of the release (EC50 = 8.2 μM) than the d-isomer (EC50 = 12.3 μM). This enhanced release by l-synephrine was blocked by nisoxetine. Properties Name 4-[1-hydroxy-2-(methylamino)ethyl]phenol,hydrochloride Synonym More Synonyms Synephrine hydrochloride Biological Activity Description Synephrine Hcl(Oxedrine) is an alkaloid; synephrine produces most of its biological effects by acting as an agonist at adrenergic receptors.IC50 value:Target: adrenergic receptor agonistThere is some evidence that synephrine also has weak activity at 5-HT receptors, and that it interacts with TAAR1 (trace adrenergic amine receptors). d-synephrine inhibited the uptake of [3H]-norepinephrine with an IC50 = 5.8 μM; l-synephrine was less potent (IC50 = 13.5 μM). d-Synephrine also competitively inhibited the binding of nisoxetine[m] to rat brain cortical slices, with a Ki = 4.5 μM; l-synephrine was less potent (Ki = 8.2 μM). In experiments on the release of [3H]-norepinephrine from rat brain cortical slices, however, the l-isomer of synephrine was a more potent enhancer of the release (EC50 = 8.2 μM) than the d-isomer (EC50 = 12.3 μM). This enhanced release by l-synephrine was blocked by nisoxetine. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Natural Products >> Alkaloid Research Areas >> Neurological Disease References [1]. Synephrine, From Wikipedia Chemical & Physical Properties Exact Mass 203.071304 PSA 52.49000 LogP 1.83790 InChIKey COTCEGYSNTWJQV-UHFFFAOYSA-N Storage condition Refrigerator Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Benzyl alcohol, p-hydroxy-alpha-((methylamino)methyl)-, hydrochloride CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : QR DYQ1M1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 124,231,1927 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 124,231,1927 Safety Information Hazard Codes Xi HS Code 2922199090 Precursor & DownStream Precursor 0 DownStream 1 CAS#:14593-25-0 Compound A
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