![3-(5-Methylisoxazol-3-yl)-6-[(1-methyl-1H-1,2,3-triazol-4-yl)methoxy][1,2,4]triazolo[3,4-a]phthalazine structure, CAS 215874-86-5](/structures/100000/87031_3_215874_86_5.png)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 215874-86-5 |
| Catalog No. | 2A-9087031 |
| Chinese Name | 3-(5-甲基-3-异噁唑基)-6-[(1-甲基-1H-1,2,3-三氮唑-4-基)甲氧基][1,2,4]三氮唑并[3,4-a]酞嗪 |
| Synonyms | 3-(5-methylisoazol-3-yl)-6-[(1-methyl-1,2,3-triazol-4-yl)methyloxy]-1,2,4-triazolo[3,4-a]phthalazine; | inverted exclamation mark5IA; |A5IA |
| Molecular Formula | C17H14N8O2 |
| Molecular Weight | 362.34500 |
| Storage Condition | room temperature, dry |
| Application | α5IA (L-822179) is a selective α5-GABAA receptor inverse agonist with neuroprotective potential [1]. |
| HTC | 2934999090 |
| Bioactivity | α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor In Vitro α5IA (100 nM, 5 days) Can significantly reduce Aβ 1-42-induced cell death in primary mouse hippocampal cultures [1]. Cell Viability Assay[1] Cell Line: Primary mouse hippocampal culture Concentration: 0.3 nM, 3 nM, 30 nM, 100 nM Incubation Time: 24 h Result: Significantly reduced Aβ 1-42-induced cell death by 13% at a concentration of 100 nM. Significantly decreased the expression of GABAAR α5 subunit. In Vivo α5IA (5 mg/kg, i.p., once) sustainably restores spatial learning ability and long-term recognition spatial memory deficits in Ts65Dn mice [2]. References [1]. Chitra Vinnakota, et al. An 5 GABAA Receptor Inverse Agonist, 5IA, Attenuates Amyloid Beta-Induced Neuronal Death in Mouse Hippocampal Cultures. Int J Mol Sci. 2020 May 6;21(9):3284. [2]. Arnaud Duchon, et al. Long-lasting correction of in vivo LTP and cognitive deficits of mice modeling Down syndrome with an α5-selective GABAA inverse agonist. Br J Pharmacol. 2020 Mar;177(5):1106-1118. Chemical & Physical Properties Molecular Formula C17H14N8O2 Molecular Weight 362.34500 Exact Mass 362.12400 PSA 109.05000 LogP 1.94840 |
| Use of | α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential[1]. Properties Name 5-methyl-3-[6-[(1-methyltriazol-4-yl)methoxy]-[1,2,4]triazolo[3,4-a]phthalazin-3-yl]-1,2-oxazole Synonym More Synonyms Α5ia (α5IA) Biological Activity Description α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor In Vitro α5IA (100 nM, 5 days) Can significantly reduce Aβ 1-42-induced cell death in primary mouse hippocampal cultures [1]. Cell Viability Assay[1] Cell Line: Primary mouse hippocampal culture Concentration: 0.3 nM, 3 nM, 30 nM, 100 nM Incubation Time: 24 h Result: Significantly reduced Aβ 1-42-induced cell death by 13% at a concentration of 100 nM. Significantly decreased the expression of GABAAR α5 subunit. References [1]. Chitra Vinnakota, et al. An 5 GABAA Receptor Inverse Agonist, 5IA, Attenuates Amyloid Beta-Induced Neuronal Death in Mouse Hippocampal Cultures. Int J Mol Sci. 2020 May 6;21(9):3284. [2]. Arnaud Duchon, et al. α5-selective GABAA inverse agonist. Br J Pharmacol. 2020 Mar;177(5):1106-1118. Chemical & Physical Properties Molecular Formula C17H14N8O2 Exact Mass 362.12400 PSA 109.05000 LogP 1.94840 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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