CAS Number76963-41-2
SynonymsTazac; Acinon; Nizax; N-[2[[[2-[(dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine; Cronizat; Axid; MFCD00865660; Galitidin; Distaxid; Nizatidine; Zanizal; Calmaxid
Molecular FormulaC12H21N5O2S2
Molecular Weight331.46
Purity98%
Density1.2±0.1 g/cm3
Boiling Point478.2±45.0 °C at 760 mmHg
Melting Point130-132ºC
AppearanceWhite to off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 76963-41-2 |
| Catalog No. | 2A-9008562 |
| Chinese Name | 尼扎替丁 |
| Synonyms | Tazac; Acinon; Nizax; N-[2[[[2-[(dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine; Cronizat; Axid; MFCD00865660; Galitidin; Distaxid; Nizatidine; Zanizal; Calmaxid |
| Molecular Formula | C12H21N5O2S2 |
| Molecular Weight | 331.46 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 478.2±45.0 °C at 760 mmHg |
| Melting Point | 130-132ºC |
| Appearance | White to off-white crystalline powder |
| Storage Condition | -20?C Freezer |
| Application | Nizatidine is a histamine H2 receptor antagonist with low toxicity and can inhibit gastric acid secretion. |
| HTC | 2934999090 |
| SMILES | [s]1c(nc(c1)CSCCN\C(=C\[N+](=O)[O-])\NC)CN(C)C |
| InChI | 1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3/b11-6+ |
| InChI Key | SGXXNSQHWDMGGP-IZZDOVSWSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/8562_2_76963_41_2.pdf |
| Bioactivity | Nizatidine is a histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion.Target: Histamine H2 ReceptorNizatidine, a selective histamine H2-receptor antagonist, is a potent inhibitor of gastric acid secretion, with IC50 of 0.9 nM. Nizatidine exhibits maximal inhibition of gastric acid in rats within the first hour of drug administration, with EC50 of 1.383 μmol/kg [1]. Nizatidine also reversibly inhibits acetylcholinesterase (AChE), with IC50 of 6.7 μM, and the inhibition is noncompetitive, with a Ki value of 7.4 μM. Nizatidine (0.3-3 mg/kg, i.v.) significantly increases the motor index of gastrointestinal (GI) motility in a dose-dependent manner. Nizatidine inhibits gastric acid secretion with ED50 and ED90 of 0.18 and 3.22 mg/kg in dogs, and 2.94 and 19.6 mg/kg in rats, respectively [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. Lin, T.M., et al., Actions of nizatidine, a selective histamine H2-receptor antagonist, on gastric acid secretion in dogs, rats and frogs. J Pharmacol Exp Ther, 1986. 239(2): p. 406-10. [2]. Ueki, S., et al., Gastroprokinetic activity of nizatidine, a new H2-receptor antagonist, and its possible mechanism of action in dogs and rats. J Pharmacol Exp Ther, 1993. 264(1): p. 152-7. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 478.2±45.0 °C at 760 mmHg Melting Point 130-132ºC Molecular Formula C12H21N5O2S2 Molecular Weight 331.457 Flash Point 243.0±28.7 °C Exact Mass 331.113678 PSA 139.55000 LogP 1.18 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.592 InChIKey SGXXNSQHWDMGGP-IZZDOVSWSA-N SMILES CNC(=C[N+](=O)[O-])NCCSCc1csc(CN(C)C)n1 Storage condition -20?C Freezer |
| Use of | Properties Articles32 Name nizatidine Synonym More Synonyms Nizatidine Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. Lin, T.M., et al., Actions of nizatidine, a selective histamine H2-receptor antagonist, on gastric acid secretion in dogs, rats and frogs. J Pharmacol Exp Ther, 1986. 239(2): p. 406-10. [2]. Ueki, S., et al., Gastroprokinetic activity of nizatidine, a new H2-receptor antagonist, and its possible mechanism of action in dogs and rats. J Pharmacol Exp Ther, 1993. 264(1): p. 152-7. Chemical & Physical Properties Molecular Formula C12H21N5O2S2 Exact Mass 331.113678 PSA 139.55000 Index of Refraction 1.592 InChIKey SGXXNSQHWDMGGP-IZZDOVSWSA-N Storage condition -20?C Freezer |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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