![5,11-Dimethylpyrido[4,3-B]carbazole structure, CAS 519-23-3](/structures/100000/85459_1_519_23_3.png)
CAS Number519-23-3
SynonymsMFCD00010524; 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole; EINECS 208-264-0; tcmdc-125546; ELLIPTICINE; Elliptisine
Molecular FormulaC17H14N2
Molecular Weight246.31
Purity≥99 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point495.4±40.0 °C at 760 mmHg
Melting Point316-318°C
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 519-23-3 |
| Catalog No. | 2A-9085459 |
| Chinese Name | 椭圆玫瑰树碱溶液 |
| Synonyms | MFCD00010524; 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole; EINECS 208-264-0; tcmdc-125546; ELLIPTICINE; Elliptisine |
| Molecular Formula | C17H14N2 |
| Molecular Weight | 246.31 |
| Purity | ≥99 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 495.4±40.0 °C at 760 mmHg |
| Melting Point | 316-318°C |
| Appearance | solid |
| Water Solubility | DMSO: soluble |
| Storage Condition | Store in a cool, dry, well-ventilated warehouse at |
| Packaging | III |
| Application | Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activity. |
| HTC | 2933990090 |
| MDL Number | MFCD00010524 |
| SMILES | [nH]1c2c(c4c1cccc4)c(c3c(c2C)ccnc3)C |
| InChI | 1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3 |
| InChI Key | CTSPAMFJBXKSOY-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/85459_1_519_23_3.pdf |
| Use of | Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. Properties Name ellipticine Synonym More Synonyms ELLIPTICINE Biological Activity Description Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. Related Catalog Research Areas >> Cancer Natural Products >> Alkaloid Topoisomerase II In Vitro Ellipticine is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of ellipticine antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of ellipticine action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases[1]. Ellipticine can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with ellipticine results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent ellipticine-derived DNA adducts[2]. References [1]. Stiborova M, et al. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):13-23. [2]. Stiborova M, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011 Jun;4(2):98-105. Chemical & Physical Properties Molecular Formula C17H14N2 Exact Mass 246.115692 PSA 28.68000 Index of Refraction 1.777 Water Solubility DMSO: soluble Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 6H-Pyrido(4,3-b)carbazole, 5,11-dimethyl- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C17-H14-N2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T D6 B656 FN LMJ C1 J1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 19500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : Cytogenetic analysis MUTATION DATA TYPE OF TEST : DNA adduct TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : REFERENCE : Safety Information Hazard Codes T Risk Phrases 25 Safety Phrases S45 WGK Germany 3 RTECS UU8825000 Packaging Group III Hazard Class 6.1(b) HS Code 2933990090 Synthetic Route N-[(1,4-dimethy... 65266-47-9 ELLIPTICINE Literature: Vehar, Blaz; Hrast, Martina; Kovac, Andreja; Konc, Janez; Mariner, Katherine; Chopra, Ian; O'Neill, Alex; Janezic, Dusanka; Gobec, Stanislav Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 17 p. 5137 - 5146 65266-48-0 ELLIPTICINE Literature: Mustafin; Khalilov; Ismagilov; Baimetov; Spirikhin; Abdrakhmanov; Tolstikov Russian Chemical Bulletin, 1999 , vol. 48, # 11 p. 2121 - 2126 tert-butyl 5,11... 260430-53-3 ELLIPTICINE Literature: Ishikura, Minoru; Hino, Ayako; Yaginuma, Toshikatsu; Agata, Isao; Katagiri, Nobuya Tetrahedron, 2000 , vol. 56, # 2 p. 193 - 207 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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