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Home > Products > Pharmaceutical R&D Materials > Heterocyclic Building Blocks > 2-Amino-3,4-dimethyl-3H-imidazo[4,5-F]quinoline
2-Amino-3,4-dimethyl-3H-imidazo[4,5-F]quinoline structure, CAS 77094-11-2

2-Amino-3,4-dimethyl-3H-imidazo[4,5-F]quinoline

CAS Number77094-11-2

SynonymsMethyl IQ; Me IQ; 3,4-dimethyl-3H-imidazo<quinolin-2-amine; MelQ; 2-amino-3,4-dimethylimidazo<4,5-f>quinoline

Molecular FormulaC12H12N4

Molecular Weight212.25000

Purity

Density1.36g/cm3

Boiling Point465.7ºC at 760 mmHg

Melting Point291-293ºC

Flash Point

Appearance

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Cat. No.: 2A-9085383 Purity:
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Quality Control of [ 77094-11-2 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number77094-11-2
Catalog No.2A-9085383
Chinese Name2-氨基-3,4-二甲基-3H-咪唑并喹啉
SynonymsMethyl IQ; Me IQ; 3,4-dimethyl-3H-imidazo<quinolin-2-amine; MelQ; 2-amino-3,4-dimethylimidazo<4,5-f>quinoline
Molecular FormulaC12H12N4
Molecular Weight212.25000
Density1.36g/cm3
Boiling Point465.7ºC at 760 mmHg
Melting Point291-293ºC
Storage ConditionWarehouse ventilation and low temperature drying
ApplicationMe IQ (methyl IQ) is an orally active heterocyclic amine with carcinogenic and mutagenic effects. Me IQ is several hundred times more mutagenic in the liver than uninduced lung microsomal preparations
HTC2933990090
SMILESCc1cc2ncccc2c2nc(N)n(C)c12
InChIInChI=1S/C12H12N4/c1-7-6-9-8(4-3-5-14-9)10-11(7)16(2)12(13)15-10/h3-6H,1-2H3,(H2,13,15)
InChI KeyGMGWMIJIGUYNAY-UHFFFAOYSA-N
Use ofMe-IQ (Methyl-IQ), an orally active heterocyclic amine, is carcinogenic and mutagenic. Me-IQ is several hundred-fold more mutagenic in liver than in lung microsomal preparations from uninduced mice and rabbits[1][2]. Properties Name 3,4-dimethylimidazo[4,5-f]quinolin-2-amine Synonym More Synonyms MeIQ Biological Activity Description Me-IQ (Methyl-IQ), an orally active heterocyclic amine, is carcinogenic and mutagenic. Me-IQ is several hundred-fold more mutagenic in liver than in lung microsomal preparations from uninduced mice and rabbits[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others In Vitro Me-IQ (Methyl-IQ; diet containing 0.04% or 0.01%) Resulting in a high incidence of squamous cell carcinoma and papilloma in the forestomach of mice. Approximately 40% of forestomach squamous cell carcinomas induced by Me-IQ at the 0.04% dose group metastasized to the liver [1]. References [1]. H Ohgaki, et al. Carcinogenicities in mice and rats of IQ, MeIQ, and MeIQx. Princess Takamatsu Symp. 1985;16:97-105. [2]. T Aune, et al. Mutagenic activation of IQ and Me-IQ by liver and lung microsomes from rabbit and mouse, and with isolated lung cells from the rabbit. Carcinogenesis. 1986 Feb;7(2):273-6. Chemical & Physical Properties Molecular Formula C12H12N4 Exact Mass 212.10600 PSA 56.73000 LogP 2.59330 Index of Refraction 1.725 InChIKey GMGWMIJIGUYNAY-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 3H-Imidazo(4,5-f)quinoline, 2-amino-3,4-dimethyl- CAS REGISTRY NUMBER : 77094-11-2 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C12-H12-N4 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Endocrine - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors TYPE OF TEST : Specific locus test TYPE OF TEST : Morphological transformation TYPE OF TEST : DNA damage TYPE OF TEST : DNA damage TYPE OF TEST : DNA damage TYPE OF TEST : Sister chromatid exchange MUTATION DATA TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - guinea pig Lung DOSE/DURATION : REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,245,1985 *** REVIEWS *** IARC Cancer Review: Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Center USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Center USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,275,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Center USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,275,1986 IARC Cancer Review: Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Center USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Center USA, 49 Sheridan Ave., Albany, NY 12210) 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993 Safety Information Hazard Codes T: Toxic; HS Code 2933990090 Synthetic Route 6-Quinolinamine... 83407-40-3 77094-11-2 Literature: Chemical and Pharmaceutical Bulletin, , vol. 30, # 5 p. 1857 - 1859 7-methyl-6-form... 83407-44-7 77094-11-2 Literature: Chemical and Pharmaceutical Bulletin, , vol. 30, # 5 p. 1857 - 1859 Cyanogen bromid... 6-N,7-dimethylq... 83407-42-5 77094-11-2 Literature: Chemical and Pharmaceutical Bulletin, , vol. 30, # 5 p. 1857 - 1859
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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