CAS Number57078-98-5
Synonyms4-(2,5-dioxopyrrol-1-yl)butanoic acid; 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic acid; MFCD00043139; 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-butyric acid
Molecular FormulaC8H9NO4
Molecular Weight183.16
Purity≥98.0 (T)%
Density1.4±0.1 g/cm3
Boiling Point400.1±28.0 °C at 760 mmHg
Melting Point95-98 °C
Appearancewhite solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 57078-98-5 |
| Catalog No. | 2A-9085240 |
| Chinese Name | 4-马来酰亚胺丁酸 |
| Synonyms | 4-(2,5-dioxopyrrol-1-yl)butanoic acid; 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic acid; MFCD00043139; 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-butyric acid |
| Molecular Formula | C8H9NO4 |
| Molecular Weight | 183.16 |
| Purity | ≥98.0 (T) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 400.1±28.0 °C at 760 mmHg |
| Melting Point | 95-98 °C |
| Appearance | white solid |
| Storage Condition | 2-8°C |
| Application | 4-Maleimidobutyric acid is a PROTAC linker, belonging to the alkyl chain class. Can be used to synthesize PROTAC molecules. |
| PubChem ID | 329759801 |
| MDL Number | MFCD00043139 |
| SMILES | OC(=O)CCCN1C(=O)C=CC1=O |
| InChI | 1S/C8H9NO4/c10-6-3-4-7(11)9(6)5-1-2-8(12)13/h3-4H,1-2,5H2,(H,12,13) |
| InChI Key | NCPQROHLJFARLL-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1455876 |
| NACRES Code | NA.25 |
| UNSPSC | 12352106 |
| Hazard Symbols | transportation |
| MSDS | msds/85240_1_57078_98_5.pdf |
| Bioactivity | 4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target Alkyl-Chain In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 400.1±28.0 °C at 760 mmHg Melting Point 95-98ºC Molecular Formula C8H9NO4 Molecular Weight 183.161 Flash Point 195.8±24.0 °C Exact Mass 183.053162 PSA 74.68000 LogP 0.40 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.553 InChIKey NCPQROHLJFARLL-UHFFFAOYSA-N SMILES O=C(O)CCCN1C(=O)C=CC1=O Storage condition 2-8°C |
| Use of | 4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name 4-Maleimidobutyric Acid Synonym More Synonyms Biological Activity Description 4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl-Chain In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C8H9NO4 Exact Mass 183.053162 PSA 74.68000 Index of Refraction 1.553 InChIKey NCPQROHLJFARLL-UHFFFAOYSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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