CAS Number141699-55-0
Synonyms1-N-Boc-3-hydroxyazetidine; 1-(tert-Butoxycarbonyl)-3-hydroxyazetidine; MFCD04115305; tert-Butyl 3-Hydroxyazetidine-1-carboxylate; 3-Hydroxyazetidine-1-carboxylic Acid tert-Butyl Ester; 1-BOC-3-Hydroxyazetidine; N-Boc-3-hydroxyazetidine
Molecular FormulaC8H15NO3
Molecular Weight173.21
Purity97%
Density1.2±0.1 g/cm3
Boiling Point253.7±33.0 °C at 760 mmHg
Melting Point36-43 °C
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 141699-55-0 |
| Catalog No. | 2A-9008503 |
| Chinese Name | 1-Boc-3-羟基吖丁啶 |
| Synonyms | 1-N-Boc-3-hydroxyazetidine; 1-(tert-Butoxycarbonyl)-3-hydroxyazetidine; MFCD04115305; tert-Butyl 3-Hydroxyazetidine-1-carboxylate; 3-Hydroxyazetidine-1-carboxylic Acid tert-Butyl Ester; 1-BOC-3-Hydroxyazetidine; N-Boc-3-hydroxyazetidine |
| Molecular Formula | C8H15NO3 |
| Molecular Weight | 173.21 |
| Purity | 97 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 253.7±33.0 °C at 760 mmHg |
| Melting Point | 36-43 °C |
| Appearance | solid |
| Water Solubility | Soluble in: methanol |
| Storage Condition | Keep the receptacle sealed, stored in a cool, dry |
| Application | 1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADC). 1-N-Boc-3-Hydroxyazetidine is also an alkyl chain-based PROTAC linker and can be used |
| HTC | 2933990090 |
| PubChem ID | 329761653 |
| MDL Number | MFCD04115305 |
| SMILES | CC(C)(C)OC(=O)N1CC(O)C1 |
| InChI | 1S/C8H15NO3/c1-8(2,3)12-7(11)9-4-6(10)5-9/h6,10H,4-5H2,1-3H3 |
| InChI Key | XRRXRQJQQKMFBC-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Xn |
| Risk Codes | R22-36/37/38-41 |
| Safety Description | S26-36/37/39 |
| MSDS | msds/8503_2_141699_55_0.pdf |
| Bioactivity | 1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 253.7±33.0 °C at 760 mmHg Melting Point 42-44°C Molecular Formula C8H15NO3 Molecular Weight 173.210 Flash Point 107.2±25.4 °C Exact Mass 173.105194 PSA 49.77000 LogP -0.17 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.511 InChIKey XRRXRQJQQKMFBC-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)N1CC(O)C1 Storage condition 2-8°C |
| Use of | 1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs Properties Name 1-Boc-3-hydroxyazetidine Synonym More Synonyms 1-N-Boc-3-hydroxyazetidine Biological Activity Description 1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C8H15NO3 Exact Mass 173.105194 PSA 49.77000 LogP -0.17 Index of Refraction 1.511 InChIKey XRRXRQJQQKMFBC-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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