CAS Number2373-89-9
SynonymsMFCD00025815; DIMETHOXYCHALCONE,4,4'-(RG); 4,4'-dimethoxy-chalcone; 1,3-bis-{4-methoxy-phenyl}-propen-(1)-one-(3); 1,3-bis-(4-methoxyphenyl)-propenone; 2-Propen-1-one,1,3-bis(4-methoxyphenyl); 1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE; (E)-1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE; DIMETHOXYCHALCONE,4,4'; 4,4'-Dimethoxy-chalkon
Molecular FormulaC17H16O3
Molecular Weight268.31
Density1.128g/cm3
Boiling Point444.6ºC at 760 mmHg
Melting Point101°C
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2373-89-9 |
| Catalog No. | 2A-9084978 |
| Chinese Name | 4,4'-二甲氧基查耳酮 |
| Synonyms | MFCD00025815; DIMETHOXYCHALCONE,4,4'-(RG); 4,4'-dimethoxy-chalcone; 1,3-bis-{4-methoxy-phenyl}-propen-(1)-one-(3); 1,3-bis-(4-methoxyphenyl)-propenone; 2-Propen-1-one,1,3-bis(4-methoxyphenyl); 1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE; (E)-1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE; DIMETHOXYCHALCONE,4,4'; 4,4'-Dimethoxy-chalkon |
| Molecular Formula | C17H16O3 |
| Molecular Weight | 268.31 |
| Density | 1.128g/cm3 |
| Boiling Point | 444.6ºC at 760 mmHg |
| Melting Point | 101°C |
| Storage Condition | Keep container sealed, placed in a tight-fitting c |
| Application | 4,4'-Dimethoxychalcone can be isolated from the plant Angelica sinensis. It is a natural autophagy inducer and has anti-aging activity. |
| HTC | 2914509090 |
| MDL Number | MFCD00025815 |
| SMILES | COc1ccc(/C=C/C(=O)c2ccc(OC)cc2)cc1 |
| InChI | InChI=1S/C17H16O3/c1-19-15-8-3-13(4-9-15)5-12-17(18)14-6-10-16(20-2)11-7-14/h3-12H,1-2H3/b12-5+ |
| InChI Key | InChIKey=HDXVSZWKIHQDES-LFYBBSHMSA-N |
| MSDS | msds/84978_1_2373_89_9.pdf |
| Bioactivity | 4,4'-Dimethoxychalcone, isolated from the plant Angelica keiskei koidzumi, acts as a natural autophagy inducer with anti-ageing properties[1]. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Metabolic Disease Target Autophagy[1] In Vivo The flavonoid 4,4'-Dimethoxychalcone acts as an anti-ageing compound with cardioprotective effects in mice and the potential to promote longevity across species[1]. 4,4'-Dimethoxychalcone (100 mg/kg; intraperitoneally) efficiently triggered autophagic flux in the heart and liver from wild type (WT) C57BL/6 mice[1]. Animal Model: 6-week-old male wild type C57BL/6 or Atg4b-/- mice[1] Dosage: 100 mg/kg Administration: Injected intraperitoneally with a single Result: Triggered autophagic flux in the heart and liver. References [1]. Carmona-Gutierrez D, et al. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019 Feb 19;10(1):651. Chemical & Physical Properties Density 1.128g/cm3 Boiling Point 444.6ºC at 760 mmHg Melting Point 101°C Molecular Formula C17H16O3 Molecular Weight 268.30700 Flash Point 214.6ºC Exact Mass 268.11000 PSA 35.53000 LogP 3.59990 Vapour Pressure 4.23E-08mmHg at 25°C Index of Refraction 1.591 |
| Use of | 4,4'-Dimethoxychalcone, isolated from the plant Angelica keiskei koidzumi, acts as a natural autophagy inducer with anti-ageing properties[1]. Properties Name 4,4'-dimethoxychalcone Synonym More Synonyms 2-Propen-1-one,1,3-bis(4-methoxyphenyl) Biological Activity Description 4,4'-Dimethoxychalcone, isolated from the plant Angelica keiskei koidzumi, acts as a natural autophagy inducer with anti-ageing properties[1]. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Metabolic Disease Autophagy[1] References [1]. Carmona-Gutierrez D, et al. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019 Feb 19;10(1):651. Chemical & Physical Properties Molecular Formula C17H16O3 Exact Mass 268.11000 PSA 35.53000 LogP 3.59990 Index of Refraction 1.591 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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