CAS Number5784-74-7
Synonymsrac-salsolidine; 6,7-DIMETHOXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE; 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylisoquinoline; 1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline; Salsolidine
Molecular FormulaC12H18O2N1Cl1
Molecular Weight243.73
Density1.034g/cm3
Boiling Point313.4ºC at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5784-74-7 |
| Catalog No. | 2A-9084695 |
| Chinese Name | 6,7-二甲氧基-1-甲基-1,2,3,4-四氢异喹啉 |
| Synonyms | rac-salsolidine; 6,7-DIMETHOXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE; 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylisoquinoline; 1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline; Salsolidine |
| Molecular Formula | C12H18O2N1Cl1 |
| Molecular Weight | 243.73 |
| Density | 1.034g/cm3 |
| Boiling Point | 313.4ºC at 760 mmHg |
| Storage Condition | 2-8℃ |
| Application | Salsolidine is a tetrahydroisoquinoline alkaloid that can stereoselectively and competitively inhibit the activity of MAO A. |
| HTC | 2933499090 |
| MDL Number | MFCD00050647 |
| SMILES | COc1cc2c(cc1OC)C(C)NCC2 |
| InChI | InChI=1S/C12H17NO2.ClH/c1-8-10-7-12(15-3)11(14-2)6-9(10)4-5-13-8;/h6-8,13H,4-5H2,1-3H3;1H |
| InChI Key | HMYJLVDKPJHJCF-UHFFFAOYSA-N |
| MSDS | msds/84695_1_5784_74_7.pdf |
| Use of | Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. Properties Name 6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline Synonym More Synonyms Salsolidine Biological Activity Description Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. Related Catalog Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Natural Products >> Alkaloid Research Areas >> Neurological Disease In Vitro Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. The R-salsolidine is more active against MAO A than S-salsolidine (Ki, 6 μM and 186 μM)[1]. Salsolidine weakly inhibits the binding of δ-receptor, with a Ki of >100 μM[2]. Salsolidine has the potential of inhibiting Acetylcholinestearse and butyrylcholinesterase[3]. References [1]. Bembenek ME, et al. Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. J Med Chem. 1990 Jan;33(1):147-52. [2]. Airaksinen MM, et al. Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta-type. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):380-5. [3]. Tundis R, et al. A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2009 Jun;24(3):818-24. Chemical & Physical Properties Molecular Formula C12H17NO2 Exact Mass 207.12600 PSA 30.49000 LogP 2.23930 InChIKey HMYJLVDKPJHJCF-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information Hazard Codes Xi HS Code 2933499090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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