CAS Number102146-07-6
Synonyms8-Cyclopentyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione; 8-cyclopentyl-1,3-dipropyl-7H-purine-2,6-dione; MFCD00055117
Molecular FormulaC16H24N4O2
Molecular Weight304.39
Density1.195g/cm3
Boiling Point535.1ºC at 760mmHg
Melting Point178°C
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 102146-07-6 |
| Catalog No. | 2A-9084409 |
| Chinese Name | 1,3-二丙基-8-环戊基黄嘌呤 |
| Synonyms | 8-Cyclopentyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione; 8-cyclopentyl-1,3-dipropyl-7H-purine-2,6-dione; MFCD00055117 |
| Molecular Formula | C16H24N4O2 |
| Molecular Weight | 304.39 |
| Density | 1.195g/cm3 |
| Boiling Point | 535.1ºC at 760mmHg |
| Melting Point | 178°C |
| Appearance | solid |
| Water Solubility | DMSO: >10 mg/mL |
| Storage Condition | Store airtight in a cool, dry warehouse. |
| Application | DPCPX (PD 116948) is a xanthine derivative and a highly potent and selective adenosine A1 receptor antagonist with a Ki value of 0.46 nM. |
| HTC | 2933990090 |
| PubChem ID | 24277697 |
| MDL Number | MFCD00055117 |
| SMILES | CCCN1C(=O)N(CCC)c2nc([nH]c2C1=O)C3CCCC3 |
| InChI | 1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18) |
| InChI Key | FFBDFADSZUINTG-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352202 |
| Hazard Symbols | transportation |
| MSDS | msds/84409_1_102146_07_6.pdf |
| Bioactivity | DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes[1][2][3]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Target Ki: 0.46 nM (3H-CHA binding to A1 receptors in rat whole brain membranes); 340 nM (3H-NECA binding to A2 receptors in rat striatal membranes)[2]. In Vivo DPCPX (PD 116948) ( 0.1, 0.3 and 1.0 mg/kg i.v. ) produces significant dose-related increases (P<0.05) in urine volume and in urinary sodium, potassium and chloride excretion[3]. References [1]. S J Haleen, et al. PD 116,948, a Highly Selective A1 Adenosine Receptor Antagonist. Life Sci. 1987 Feb 9;40(6):555-61. [2]. R F Bruns, et al. Binding of the A1-selective Adenosine Antagonist 8-cyclopentyl-1,3-dipropylxanthine to Rat Brain Membranes. Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335(1):59-63. [3]. POSTER COMMUNICATIONS Part II. Br J Pharmacol. 1989 Jul; 97(Suppl): 496P-535P. Chemical & Physical Properties Density 1.195g/cm3 Boiling Point 535.1ºC at 760mmHg Melting Point 178°C Molecular Formula C16H24N4O2 Molecular Weight 304.38700 Flash Point 277.4ºC Exact Mass 304.19000 PSA 72.68000 LogP 2.36390 Appearance of Characters solid | white Vapour Pressure 1.59E-11mmHg at 25°C Index of Refraction 1.564 InChIKey FFBDFADSZUINTG-UHFFFAOYSA-N SMILES CCCn1c(=O)c2[nH]c(C3CCCC3)nc2n(CCC)c1=O Storage condition Store at RT Stability Store tightly sealed at RT; Solutions at 4 deg C for several days Water Solubility DMSO: >10 mg/mL |
| Use of | DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes[1][2][3]. Properties Articles91 Name 8-Cyclopentyl-1,3-dipropylxanthine Synonym More Synonyms DPCPX Biological Activity Description DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes[1][2][3]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Ki: 0.46 nM (3H-CHA binding to A1 receptors in rat whole brain membranes); 340 nM (3H-NECA binding to A2 receptors in rat striatal membranes)[2]. References [1]. S J Haleen, et al. PD 116,948, a Highly Selective A1 Adenosine Receptor Antagonist. Life Sci. 1987 Feb 9;40(6):555-61. [2]. R F Bruns, et al. Binding of the A1-selective Adenosine Antagonist 8-cyclopentyl-1,3-dipropylxanthine to Rat Brain Membranes. Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335(1):59-63. [3]. POSTER COMMUNICATIONS Part II. Br J Pharmacol. 1989 Jul; 97(Suppl): 496P-535P. Chemical & Physical Properties Molecular Formula C16H24N4O2 Exact Mass 304.19000 PSA 72.68000 LogP 2.36390 Appearance of Characters solid | white Index of Refraction 1.564 InChIKey FFBDFADSZUINTG-UHFFFAOYSA-N Storage condition Store at RT Stability Store tightly sealed at RT; Solutions at 4 deg C for several days |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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