CAS Number153436-53-4
SynonymsAG-1478 hydrochloride; n-(3-chlorphenyl)-6,7-dimethoxy-4-chinazolinamin; AG-1478; Tyrphostin AG 1478; 4-(3-Chloro-benzyl)-6,7-dimethoxy-quinazoline; N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine
Molecular FormulaC16H14O2N3Cl1
Molecular Weight315.76
Density1.3±0.1 g/cm3
Boiling Point458.5±45.0 °C at 760 mmHg
Melting Point247 °C(dec.)
AppearanceSolid;Light orange to Yellow to Green powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 153436-53-4 |
| Catalog No. | 2A-9084350 |
| Chinese Name | 4-(3-氯苯胺)-6,7-二甲氧基喹唑啉盐酸盐 |
| Synonyms | AG-1478 hydrochloride; n-(3-chlorphenyl)-6,7-dimethoxy-4-chinazolinamin; AG-1478; Tyrphostin AG 1478; 4-(3-Chloro-benzyl)-6,7-dimethoxy-quinazoline; N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine |
| Molecular Formula | C16H14O2N3Cl1 |
| Molecular Weight | 315.76 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 458.5±45.0 °C at 760 mmHg |
| Melting Point | 247 °C(dec.) |
| Appearance | Solid;Light orange to Yellow to Green powder to crystal |
| Storage Condition | Desiccate at -20°C |
| Application | AG-1478 is a selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. |
| HTC | 2933990090 |
| MDL Number | MFCD00270914 |
| SMILES | COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC |
| InChI | InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) |
| InChI Key | GFNNBHLJANVSQV-UHFFFAOYSA-N |
| MSDS | msds/84350_1_153436_53_4.pdf |
| Use of | AG-1478 is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. Properties Name N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine Synonym More Synonyms AG-1478 Biological Activity Description AG-1478 is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. Related Catalog Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Research Areas >> Cancer EGFR:3 nM (IC50) References [2]. Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580. [3]. Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215. Chemical & Physical Properties Exact Mass 315.077454 PSA 56.27000 Index of Refraction 1.668 InChIKey GFNNBHLJANVSQV-UHFFFAOYSA-N Safety Information RTECS VA0953000 HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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