![N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamidedihydrochloride structure, CAS 113276-94-1](/structures/100000/84028_1_113276_94_1.png)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 113276-94-1 |
| Catalog No. | 2A-9084028 |
| Chinese Name | H-8 二氢氯化物 |
| Synonyms | H-8 dihydrochloride; MFCD00036962 |
| Molecular Formula | C19H26O2N4S1 |
| Molecular Weight | 374.51 |
| Boiling Point | 473.9ºC at 760 mmHg |
| Melting Point | 221-222℃ (methanol water ) |
| Appearance | White to off-white crystalline solid |
| Water Solubility | ethanol: 25 mg/mL, clear, colorless |
| Storage Condition | Sealed in a cool, dry environment at 2-8 ºC |
| Application | H-8 (hydrochloric acid) is a cell-permeable, reversible and ATP-competitive PKA inhibitor [1]. |
| HTC | 2935009090 |
| MDL Number | MFCD35066975 |
| SMILES | CNCCNS(=O)(=O)c1cccc2cnccc12.Cl.Cl |
| InChI | InChI=1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H |
| InChI Key | RJJLZYZEVNCZIW-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/84028_1_113276_94_1.pdf |
| Bioactivity | H-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive PKA inhibitor[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA References [1]. Niisato N, et al. Effects of PKA inhibitors, H-compounds, on epithelial Na+ channels via PKA-independent mechanisms. Life Sci. 1999;65(10):PL109-14. Chemical & Physical Properties Boiling Point 473.9ºC at 760 mmHg Melting Point 221-222℃ (methanol water ) Molecular Formula C12H17Cl2N3O2S Molecular Weight 338.25300 Flash Point 240.4ºC Exact Mass 337.04200 PSA 79.47000 LogP 4.19910 Vapour Pressure 3.79E-09mmHg at 25°C InChIKey RJJLZYZEVNCZIW-UHFFFAOYSA-N SMILES CNCCNS(=O)(=O)c1cccc2cnccc12.Cl.Cl Storage condition 2-8°C Water Solubility ethanol: 25 mg/mL, clear, colorless |
| Use of | H-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive PKA inhibitor[1]. Properties Name N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide hydrochloride Synonym More Synonyms h-8 dihydrochloride Biological Activity Description H-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive PKA inhibitor[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA References [1]. Niisato N, et al. Effects of PKA inhibitors, H-compounds, on epithelial Na+ channels via PKA-independent mechanisms. Life Sci. 1999;65(10):PL109-14. Chemical & Physical Properties Exact Mass 337.04200 PSA 79.47000 LogP 4.19910 InChIKey RJJLZYZEVNCZIW-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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