CAS Number116-26-7
SynonymsMFCD00209531; 2,6,6-trimethylcyclohexa-1,3-dienecarbaldehyde; 2,3-Dihydro-2,2,6-trimethylbenzaldehyde; Safranal; 2,6,6-Trimethylcyclohexa-1,3-dienyl methanal; 2,6,6-trimethyl-1,3-cyclohexadiene-1-carboxaldehyde; 1,3-CYCLOHEXADIENE-1-CARBOXALDEHYDE,2,6,6-TRIMETHYL; EINECS 204-133-7; FEMA No. 3389; 2,6,6-trimethylcyclohexa-1,3-diene-1-carbaldehyde; 1,1,3-Trimethyl-2-formylcyclohexa-2,4-diene
Molecular FormulaC10H14O
Molecular Weight150.22
Purity≥90.0 (HPLC)%
Density0.975 g/cm3
Boiling Point70 °C/1 mmHg (lit.)
Appearanceliquid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 116-26-7 |
| Catalog No. | 2A-9083878 |
| Chinese Name | 2,3-二氢-2,2,6-三甲基苯甲醛 |
| Synonyms | MFCD00209531; 2,6,6-trimethylcyclohexa-1,3-dienecarbaldehyde; 2,3-Dihydro-2,2,6-trimethylbenzaldehyde; Safranal; 2,6,6-Trimethylcyclohexa-1,3-dienyl methanal; 2,6,6-trimethyl-1,3-cyclohexadiene-1-carboxaldehyde; 1,3-CYCLOHEXADIENE-1-CARBOXALDEHYDE,2,6,6-TRIMETHYL; EINECS 204-133-7; FEMA No. 3389; 2,6,6-trimethylcyclohexa-1,3-diene-1-carbaldehyde; 1,1,3-Trimethyl-2-formylcyclohexa-2,4-diene |
| Molecular Formula | C10H14O |
| Molecular Weight | 150.22 |
| Purity | ≥90.0 (HPLC) |
| Density | 0.975 g/cm3 |
| Boiling Point | 70 °C/1 mmHg (lit.) |
| Appearance | liquid |
| Storage Condition | -20°C; store under inert gas; protect from light, |
| Application | Safranal is the main, orally active component of saffron (Crocus sativus) and is the source of this spice's unique aroma. Safranal has neuroprotective and anti-inflammatory effects and has research po |
| HTC | 2912299000 |
| MDL Number | MFCD00209531 |
| SMILES | CC1=C(C=O)C(C)(C)CC=C1 |
| InChI | 1S/C10H14O/c1-8-5-4-6-10(2,3)9(8)7-11/h4-5,7H,6H2,1-3H3 |
| InChI Key | SGAWOGXMMPSZPB-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1932918 |
| UNSPSC | 41116107 |
| MSDS | msds/83878_1_116_26_7.pdf |
| Bioactivity | Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson's disease research[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease In Vitro Safranal (10-50 μM; for 1 h) dose-dependently decreases LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs[1]. Safranal (10-50 μM; for 1 h) inhibits cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells[1]. Safranal (10, 50 μM; for 1 h followed by stimulation with 1 μg/ml of LPS for 30 min) inhibits the nuclear translocation of NF-κB and AP-1 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells[1]. Western Blot Analysis[1] Cell Line: RAW264.7 cells and bone marrow-derived macrophages (BMDMs) Concentration: 10, 50 μM Incubation Time: For 1 h prior to lipopolysaccharide (LPS) stimulation (1 µg/ml) Result: Dose-dependently decreased LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs. Inhibited the phosphorylation of MAPK pathway proteins extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38. Inhibited NF-κB pathway proteins IKKα/β and IκBα and the degradation of IκBα. RT-PCR[1] Cell Line: RAW 264.7 cells Concentration: 10, 50 μM Incubation Time: For 1 h followed by stimulation with LPS (1 μg/ml) for 24 h Result: Inhibited cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. In Vivo Safranal (200-500 mg/kg; PO; for 7 days) causes a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low[1]. Animal Model: Female BALB/c mice (18-20 g) (DSS-induced colitis mice)[1] Dosage: 200, 500 mg/kg Administration: PO; for 7 days Result: Caused a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low. References [1]. Peeraphong Lertnimitphun, et al. Safranal Alleviates Dextran Sulfate Sodium-Induced Colitis and Suppresses Macrophage-Mediated Inflammation. Front Pharmacol. 2019 Nov 1;10:1281. Chemical & Physical Properties Density 0.975 g/cm3 Boiling Point 217.3ºC at 760 mmHg Molecular Formula C10H14O Molecular Weight 150.21800 Flash Point 80.4ºC Exact Mass 150.10400 PSA 17.07000 LogP 2.48790 Vapour Pressure 0.134mmHg at 25°C Index of Refraction n20/D 1.523(lit.) InChIKey SGAWOGXMMPSZPB-UHFFFAOYSA-N SMILES CC1=C(C=O)C(C)(C)CC=C1 |
| Use of | Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson's disease research[1]. Properties Articles30 Name safranal Synonym More Synonyms SAFRANAL Biological Activity Description Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson's disease research[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease References [1]. Peeraphong Lertnimitphun, et al. Safranal Alleviates Dextran Sulfate Sodium-Induced Colitis and Suppresses Macrophage-Mediated Inflammation. Front Pharmacol. 2019 Nov 1;10:1281. Chemical & Physical Properties Molecular Formula C10H14O Exact Mass 150.10400 PSA 17.07000 LogP 2.48790 InChIKey SGAWOGXMMPSZPB-UHFFFAOYSA-N SMILES CC1=C(C=O)C(C)(C)CC=C1 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 5.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2912299000. other cyclic aldehydes without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
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