CAS Number97628-92-7
Synonyms1-[(Benzyloxy)carbonyl]-3-azetidinecarboxylic acid; 1,3-Azetidinedicarboxylic acid, 1-(phenylmethyl) ester; 1-phenylmethoxycarbonylazetidine-3-carboxylic acid
Molecular FormulaC12H13NO4
Molecular Weight235.236
Density1.4±0.1 g/cm3
Boiling Point421.2±45.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 97628-92-7 |
| Catalog No. | 2A-9083727 |
| Chinese Name | 1-(苄氧基羰基)氮杂丁烷-3-羧酸 |
| Synonyms | 1-[(Benzyloxy)carbonyl]-3-azetidinecarboxylic acid; 1,3-Azetidinedicarboxylic acid, 1-(phenylmethyl) ester; 1-phenylmethoxycarbonylazetidine-3-carboxylic acid |
| Molecular Formula | C12H13NO4 |
| Molecular Weight | 235.236 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 421.2±45.0 °C at 760 mmHg |
| Storage Condition | 2-8°C |
| Application | 1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a PROTAC linker based on an alkyl ch |
| HTC | 2933990090 |
| SMILES | O=C(O)C1CN(C(=O)OCc2ccccc2)C1 |
| InChI Key | PVJPBKZGIUAESY-UHFFFAOYSA-N |
| MSDS | msds/83727_1_97628_92_7.pdf |
| Bioactivity | 1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1] Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 421.2±45.0 °C at 760 mmHg Molecular Formula C12H13NO4 Molecular Weight 235.236 Flash Point 208.5±28.7 °C Exact Mass 235.084457 PSA 66.84000 LogP 0.88 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.599 InChIKey PVJPBKZGIUAESY-UHFFFAOYSA-N SMILES O=C(O)C1CN(C(=O)OCc2ccccc2)C1 Storage condition 2-8°C |
| Use of | 1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1] Properties Name 1-Cbz-Azetidine-3-carboxylic acid Synonym More Synonyms Biological Activity Description 1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1] Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C12H13NO4 Exact Mass 235.084457 PSA 66.84000 Index of Refraction 1.599 InChIKey PVJPBKZGIUAESY-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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