| Chemical & Physical Properties | |
|---|---|
| CAS Number | 196965-14-7 |
| Catalog No. | 2A-9083147 |
| Chinese Name | 2,3-二氢-5-(甲基硫代)-n-3-吡啶-6-(三氟甲基)-(1h)-吲哚-1-羧酰胺 |
| Synonyms | 5-(Methylthio)-1-(3-pyridylcarbamoyl)-6-(trifluoromethyl)indoline; Tocris-1379 |
| Molecular Formula | C16H14F3N3OS |
| Molecular Weight | 353.36200 |
| Density | 1.43g/cm3 |
| Boiling Point | 536.2ºC at 760 mmHg |
| Application | SB221284 is a selective 5-HT2C/2B receptor antagonist with pKi values of 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors respectively. SB 221284 can be used for research on neurological dis |
| SMILES | CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2 |
| InChI Key | OQZOXHCRSXYSPM-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease[1]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Target 5-HT2A Receptor:6.4 (pKi) 5-HT2B Receptor:7.9 (pKi) 5-HT2C Receptor:8.6 (pKi) In Vivo SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801[1]. SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidine[1] Animal Model: Male Sprague Dawley rats (250-360 g)[1] Dosage: 0.1~1 mg/kg Administration: I.p. Result: Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801. Animal Model: Male Sprague Dawley rats (250-360 g)[1] Dosage: 1 mg/kg Administration: I.p. Result: Significantly enhanced the magnitude and duration of the increase induced by phencyclidine. References [1]. Hutson PH, et al. Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT(2C/2B) receptor antagonists: neurochemical and behavioural studies. Neuropharmacology. 2000;39(12):2318-2328. [2]. Bromidge SM, et al. Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines. J Med Chem. 1998;41(10):1598-1612. Chemical & Physical Properties Density 1.43g/cm3 Boiling Point 536.2ºC at 760 mmHg Molecular Formula C16H14F3N3OS Molecular Weight 353.36200 Flash Point 278.1ºC Exact Mass 353.08100 PSA 70.53000 LogP 4.55490 Vapour Pressure 1.43E-11mmHg at 25°C Index of Refraction 1.621 InChIKey OQZOXHCRSXYSPM-UHFFFAOYSA-N SMILES CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2 |
| Use of | Properties Name 5-methylsulfanyl-N-pyridin-3-yl-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide Synonym More Synonyms SB 221284 Biological Activity Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor 5-HT2A Receptor:6.4 (pKi) 5-HT2B Receptor:7.9 (pKi) References Chemical & Physical Properties Molecular Formula C16H14F3N3OS Exact Mass 353.08100 PSA 70.53000 LogP 4.55490 Index of Refraction 1.621 InChIKey OQZOXHCRSXYSPM-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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