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Melengestrol acetate structure, CAS 2919-66-6

Melengestrol acetate

CAS Number2919-66-6

SynonymsEINECS 220-859-7; 17-(acetyloxy)-6-methyl-16-methylenepregna-4,6-diene-3,20-dione; MGA; 6-methyl-16-methylidene-3,20-dioxopregna-4,6-dien-17-yl acetate; Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-16-methylene-, acetate; 17-Hydroxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione acetate; 6-Methyl-16-methylene-3,20-dioxopregna-4,6-dien-17-yl acetate; 17- (acetyloxy)-6-methyl-16-methylenepregna-4,6-diene-3,20-dione; MFCD00072142; Melengestrol acetate; 17a-Acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione; 17α-Acetoxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione

Molecular FormulaC25H32O4

Molecular Weight396.52

Purity99%

Density1.1±0.1 g/cm3

Boiling Point516.1±50.0 °C at 760 mmHg

Melting Point202-204 °C (lit.)

Flash Point

Appearancelight yellowish brown solid

EINECS220-859-7

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9008184 Purity: 99%
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Quality Control of [ 2919-66-6 ] Purity: 99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number2919-66-6
Catalog No.2A-9008184
Chinese Name醋酸美伦孕酮
SynonymsEINECS 220-859-7; 17-(acetyloxy)-6-methyl-16-methylenepregna-4,6-diene-3,20-dione; MGA; 6-methyl-16-methylidene-3,20-dioxopregna-4,6-dien-17-yl acetate; Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-16-methylene-, acetate; 17-Hydroxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione acetate; 6-Methyl-16-methylene-3,20-dioxopregna-4,6-dien-17-yl acetate; 17- (acetyloxy)-6-methyl-16-methylenepregna-4,6-diene-3,20-dione; MFCD00072142; Melengestrol acetate; 17a-Acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione; 17α-Acetoxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione
Molecular FormulaC25H32O4
Molecular Weight396.52
Purity99
Density1.1±0.1 g/cm3
Boiling Point516.1±50.0 °C at 760 mmHg
Melting Point202-204 °C (lit.)
Appearancelight yellowish brown solid
Storage Condition0-6°C
ApplicationMelenstriol acetate is a progesterone derivative that acts as an orally active corticosteroid to promote endometrial hyperplasia, pregnancy maintenance and delayed menstrual activity [1]. Melenstriol
EINECS220-859-7
PubChem ID329754737
MDL NumberMFCD00072142
SMILES[H][C@]12CC[C@@]3(C)[C@@]([H])(CC(=C)[C@]3(OC(C)=O)C(C)=O)[C@]1([H])C=C(C)C4=CC(=O)CC[C@]24C
InChI1S/C25H32O4/c1-14-11-19-20(23(5)9-7-18(28)13-21(14)23)8-10-24(6)22(19)12-15(2)25(24,16(3)26)29-17(4)27/h11,13,19-20,22H,2,7-10,12H2,1,3-6H3/t19-,20+,22+,23-,24+,25+/m1/s1
InChI KeyUDKABVSQKJNZBH-DWNQPYOZSA-N
Beilstein/REAXYS2066919
NACRES CodeNA.24
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/8184_1_2919_66_6.pdf
BioactivityMelengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2]. Related Catalog Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Cancer Research Areas >> Metabolic Disease In Vivo Melengestrol acetate (s.c.; 10 mg/kg; 9 days) inhibits the growth of AT3 tumors by approximately 53%. And it also causes a 54% weight reduction of the ventral prostate and a reduction of the seminal vesicles in adult male CCFl rats[1]. Melengestrol acetate (oral administration; 10 mg/kg; 24 days) causes a 58.8% Dunning R3327-AT3 tumors growth and reduces the adrenal weight by 51.6% in rat[1]. References [1]. G M Padilla, et al. Melengestrol acetate and megestrol acetate are prostatic tumor inhibiting agents. Biochem Cell Biol. 1990 Oct;68(10):1181-8. [2]. G W DUNCAN, et al. BIOLOGIC EFFECTS OF MELENGESTROL ACETATE. Fertil Steril. Jul-Aug 1964;15:416-32. [3]. https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/melengestrol-acetate Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 516.1±50.0 °C at 760 mmHg Melting Point 202-204ºC Molecular Formula C25H32O4 Molecular Weight 396.519 Flash Point 221.7±30.2 °C Exact Mass 396.230072 PSA 60.44000 LogP 4.21 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.555 InChIKey UDKABVSQKJNZBH-DWNQPYOZSA-N SMILES C=C1CC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC2(C)C1(OC(C)=O)C(C)=O Storage condition 0-6°C
Use ofMelengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2]. Properties Name Melengestrol Acetate Synonym More Synonyms Melengestrol acetate Biological Activity Description Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2]. Related Catalog Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Cancer Research Areas >> Metabolic Disease References [1]. G M Padilla, et al. Melengestrol acetate and megestrol acetate are prostatic tumor inhibiting agents. Biochem Cell Biol. 1990 Oct;68(10):1181-8. [2]. G W DUNCAN, et al. BIOLOGIC EFFECTS OF MELENGESTROL ACETATE. Fertil Steril. Jul-Aug 1964;15:416-32. [3]. https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/melengestrol-acetate Chemical & Physical Properties Molecular Formula C25H32O4 Exact Mass 396.230072 PSA 60.44000 Index of Refraction 1.555 InChIKey UDKABVSQKJNZBH-DWNQPYOZSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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