CAS Number168560-79-0
Synonyms1-AMINOINDAN-1,5-DICARBOXYLIC ACID,UPF 5 23; MFCD00672638; (R,S)-1-Aminoindane-1,5; Valerenic acid; 1-Amino-2,3-dihydro-1H-indene-1,5-dicarboxylic acid,1-Aminoindan-1,5-dicarboxylic acid
Molecular FormulaC11H11NO4
Molecular Weight221.21
Density1.481 g/cm3
Boiling Point470.4ºC at 760 mmHg
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 168560-79-0 |
| Catalog No. | 2A-9081487 |
| Chinese Name | 1-氨基-2,3-二氢-1H-茚-1,5-二羧酸 |
| Synonyms | 1-AMINOINDAN-1,5-DICARBOXYLIC ACID,UPF 5 23; MFCD00672638; (R,S)-1-Aminoindane-1,5; Valerenic acid; 1-Amino-2,3-dihydro-1H-indene-1,5-dicarboxylic acid,1-Aminoindan-1,5-dicarboxylic acid |
| Molecular Formula | C11H11NO4 |
| Molecular Weight | 221.21 |
| Density | 1.481 g/cm3 |
| Boiling Point | 470.4ºC at 760 mmHg |
| Appearance | solid |
| Storage Condition | Storage method: sealed below 4 °C |
| Application | UPF-523 (AIDA) is a rigid (carboxyphenyl) glycine derivative and a relatively potent and selective antagonist of group I metabotropic glutamate receptor (mGlu1a) with an IC50 of 214 μM. However, UPF-5 |
| HTC | 2922499990 |
| PubChem ID | 24277957 |
| MDL Number | MFCD00672638 |
| SMILES | NC1(CCc2cc(ccc12)C(O)=O)C(O)=O |
| InChI | 1S/C11H11NO4/c12-11(10(15)16)4-3-6-5-7(9(13)14)1-2-8(6)11/h1-2,5H,3-4,12H2,(H,13,14)(H,15,16) |
| InChI Key | LSTPKMWNRWCNLS-UHFFFAOYSA-N |
| NACRES Code | NA.32 |
| UNSPSC | 12352200 |
| MSDS | msds/81487_1_168560_79_0.pdf |
| Use of | UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis[1][2]. Properties Articles28 Name (RS)-1-Aminoindan-1,5-dicarboxylicacid Synonym More Synonyms AIDA Biological Activity Description UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis[1][2]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> mGluR mGluR1a:214 μM (IC50) References [1]. Nielsen KS, et al. Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Eur J Pharmacol. 1997;326(2-3):105-108. [2]. Zhang LP, et al. The Role of Type 1 Metabotropic Glutamate Receptors in the Generation of Dorsal Root Reflexes Induced by Acute Arthritis or the Spinal Infusion of 4-Aminopyridine in the Anesthetized Rat. J Pain. 2000;1(2):151-161. Chemical & Physical Properties Molecular Formula C11H11NO4 Exact Mass 221.06900 PSA 100.62000 LogP 1.26990 InChIKey LSTPKMWNRWCNLS-UHFFFAOYSA-N Safety Information Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter Hazard Codes Xi: Irritant; RIDADR NONH for all modes of transport HS Code 2922499990 |
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| Transport Info | Product name: Supervision conditions A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
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