| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6149-41-3 |
| Catalog No. | 2A-9081426 |
| Chinese Name | 3-羟基丙酸甲酯 |
| Synonyms | Methyl 3-hydroxypropanoate; Propanoic acid, 3-hydroxy-, methyl ester; methyl 3-hydroxypropionate |
| Molecular Formula | C4H8O3 |
| Molecular Weight | 104.104 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 180.5±0.0 °C at 760 mmHg |
| Storage Condition | room temperature, dry |
| Application | Methyl 3-hydroxypropanoate is a PROTAC linker, belonging to the alkyl/ether class. Can be used to synthesize PROTAC molecules. |
| HTC | 2918199090 |
| SMILES | COC(=O)CCO |
| InChI | InChI=1S/C4H8O3/c1-7-4(6)2-3-5/h5H,2-3H2,1H3 |
| InChI Key | RVGLEPQPVDUSOJ-UHFFFAOYSA-N |
| MSDS | msds/81426_1_6149_41_3.pdf |
| Bioactivity | Methyl 3-hydroxypropanoate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 180.5±0.0 °C at 760 mmHg Molecular Formula C4H8O3 Molecular Weight 104.104 Flash Point 72.6±12.6 °C Exact Mass 104.047340 PSA 46.53000 LogP -0.90 Vapour Pressure 0.3±0.7 mmHg at 25°C Index of Refraction 1.414 InChIKey RVGLEPQPVDUSOJ-UHFFFAOYSA-N SMILES COC(=O)CCO |
| Use of | Methyl 3-hydroxypropanoate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name Methyl 3-Hydroxypropanoate Synonym More Synonyms Methyl 3-hydroxypropanoate Biological Activity Description Methyl 3-hydroxypropanoate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C4H8O3 Exact Mass 104.047340 PSA 46.53000 LogP -0.90 Index of Refraction 1.414 InChIKey RVGLEPQPVDUSOJ-UHFFFAOYSA-N SMILES COC(=O)CCO |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff: 6.5%. General tariff:30.0% |
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