CAS Number63177-57-1
SynonymsMethyl (2E)-3-(2,5-dihydroxyphenyl)acrylate; MFCD00132932; methyl (E)-3-(2,5-dihydroxyphenyl)prop-2-enoate
Molecular FormulaC10H10O4
Molecular Weight194.19
Density1.3±0.1 g/cm3
Boiling Point400.7±35.0 °C at 760 mmHg
Melting Point178-180°C
Appearancecrystallization
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 63177-57-1 |
| Catalog No. | 2A-9081352 |
| Chinese Name | 2,5-二羟基肉桂酸甲酯 |
| Synonyms | Methyl (2E)-3-(2,5-dihydroxyphenyl)acrylate; MFCD00132932; methyl (E)-3-(2,5-dihydroxyphenyl)prop-2-enoate |
| Molecular Formula | C10H10O4 |
| Molecular Weight | 194.19 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 400.7±35.0 °C at 760 mmHg |
| Melting Point | 178-180°C |
| Appearance | crystallization |
| Water Solubility | 0.1 M NaOH: soluble |
| Storage Condition | Store at -20ºC. |
| Application | Methyl 2,5-dihydroxycinnamate is an erbstatin analogue and a stable and effective inhibitor of EGFR kinase activity [1]. |
| MDL Number | MFCD00132932 |
| SMILES | COC(=O)C=Cc1cc(O)ccc1O |
| InChI | InChI=1S/C10H10O4/c1-14-10(13)5-2-7-6-8(11)3-4-9(7)12/h2-6,11-12H,1H3/b5-2+ |
| InChI Key | BQCNSTFWSKOWMA-GORDUTHDSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/81352_1_63177_57_1.pdf |
| Bioactivity | Methyl 2,5-dihydroxycinnamate is an erbstatin analog and a stable, potent inhibitor of EGFR kinase activity[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR References [1]. Umezawa K, et al. Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors. FEBS Lett. 1990 Jan 29;260(2):198-200. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 400.7±35.0 °C at 760 mmHg Melting Point 178-180°C Molecular Formula C10H10O4 Molecular Weight 194.184 Flash Point 163.3±19.4 °C Exact Mass 194.057907 PSA 66.76000 LogP 1.51 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.629 InChIKey BQCNSTFWSKOWMA-GORDUTHDSA-N SMILES COC(=O)C=Cc1cc(O)ccc1O Storage condition −20°C Water Solubility 0.1 M NaOH: soluble |
| Use of | Methyl 2,5-dihydroxycinnamate is an erbstatin analog and a stable, potent inhibitor of EGFR kinase activity[1]. Properties Articles28 Name Methyl 2,5-Dihydroxycinnamate Synonym More Synonyms Biological Activity Description Methyl 2,5-dihydroxycinnamate is an erbstatin analog and a stable, potent inhibitor of EGFR kinase activity[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR References [1]. Umezawa K, et al. Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors. FEBS Lett. 1990 Jan 29;260(2):198-200. Chemical & Physical Properties Molecular Formula C10H10O4 Exact Mass 194.057907 PSA 66.76000 Index of Refraction 1.629 InChIKey BQCNSTFWSKOWMA-GORDUTHDSA-N Water Solubility 0.1 M NaOH: soluble |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 United Nations number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special precautions No data available |
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