CAS Number610791-05-4
Synonyms1-O-tert-butyl 3-O-methyl azetidine-1,3-dicarboxylate; 1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER
Molecular FormulaC10H17NO4
Molecular Weight215.25
Purity95%
Density1.2±0.1 g/cm3
Boiling Point269.0±33.0 °C at 760 mmHg
Appearanceliquid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 610791-05-4 |
| Catalog No. | 2A-9081273 |
| Chinese Name | N-Boc-氮杂环丁烷-3-甲酸甲酯 |
| Synonyms | 1-O-tert-butyl 3-O-methyl azetidine-1,3-dicarboxylate; 1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER |
| Molecular Formula | C10H17NO4 |
| Molecular Weight | 215.25 |
| Purity | 95 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 269.0±33.0 °C at 760 mmHg |
| Appearance | liquid |
| Storage Condition | room temperature |
| Application | 1-Boc-azetidine-3-carboxylic acid methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). 1-Boc-azetidine-3-carboxylic acid methyl ester is also a PROTAC li |
| HTC | 2933990090 |
| PubChem ID | 329768346 |
| MDL Number | MFCD06656775 |
| SMILES | CC(C)(C)OC(N(C1)CC1C(OC)=O)=O |
| InChI | 1S/C10H17NO4/c1-10(2,3)15-9(13)11-5-7(6-11)8(12)14-4/h7H,5-6H2,1-4H3 |
| InChI Key | SECFRXGVLMVUPD-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | transportation |
| MSDS | msds/81273_1_610791_05_4.pdf |
| Bioactivity | Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 269.0±33.0 °C at 760 mmHg Molecular Formula C10H17NO4 Molecular Weight 215.246 Flash Point 116.5±25.4 °C Exact Mass 215.115753 PSA 55.84000 LogP 0.73 Vapour Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.481 InChIKey SECFRXGVLMVUPD-UHFFFAOYSA-N SMILES COC(=O)C1CN(C(=O)OC(C)(C)C)C1 |
| Use of | Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 Properties Name Methyl 1-Boc-azetidine-3-carboxylate Synonym More Synonyms Biological Activity Description Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C10H17NO4 Exact Mass 215.115753 PSA 55.84000 Index of Refraction 1.481 InChIKey SECFRXGVLMVUPD-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 United Nations number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special precautions No data available |
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