| Chemical & Physical Properties | |
|---|---|
| CAS Number | 149719-06-2 |
| Catalog No. | 2A-9081174 |
| Chinese Name | 3-(哌啶-1-基)丙基 4-氨基-5-氯-2-甲氧基苯甲酸酯 盐酸盐 |
| Synonyms | Trequinsin hydrochloride |
| Molecular Formula | C16H24O3N2Cl2 |
| Molecular Weight | 363.28 |
| Boiling Point | 486.5ºC at 760 mmHg |
| Storage Condition | room temperature |
| Application | RS 23597-190 (EP-A-501322) is a high-affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits 5-HT-induced tachycardia. RS 23597-190 significantly inhibits the production of superoxide |
| HTC | 2933399090 |
| MDL Number | MFCD00672672 |
| SMILES | COc1cc(N)c(Cl)cc1C(=O)OCCCN1CCCCC1.Cl |
| InChI | InChI=1S/C16H23ClN2O3.ClH/c1-21-15-11-14(18)13(17)10-12(15)16(20)22-9-5-8-19-6-3-2-4-7-19;/h10-11H,2-9,18H2,1H3;1H |
| InChI Key | QLZLBYYNMGQIAR-UHFFFAOYSA-N |
| MSDS | msds/81174_1_149719_06_2.pdf |
| Use of | RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits 5-HT-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose[1][2]. Properties Name 3-piperidin-1-ylpropyl 4-amino-5-chloro-2-methoxybenzoate,hydrochloride Synonym More Synonyms RS 23597-190 Biological Activity Description RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits 5-HT-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor 5-HT4 Receptor References [1]. Eglen RM, et al. RS 23597-190: a potent and selective 5-HT4 receptor antagonist. Br J Pharmacol. 1993 Sep;110(1):119-26. [2]. Du Y, et al. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 2015 May;29(5):2194-204. Chemical & Physical Properties Exact Mass 362.11600 PSA 64.79000 LogP 4.28470 InChIKey QLZLBYYNMGQIAR-UHFFFAOYSA-N Safety Information Hazard Codes Xn HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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