CAS Number91300-60-6
Synonyms6-anilinoquinoline-5,8-dione; 6-(Phenylamino)quinoline-5,8-dione; 6-ANILINO-5,8-QUINOLINEDIONE; MFCD00210756
Molecular FormulaC15H10N2O2
Molecular Weight250.25
Purity≥98 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point446.9±45.0 °C at 760 mmHg
Melting Point184-185°C
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 91300-60-6 |
| Catalog No. | 2A-9080755 |
| Chinese Name | 4-苯胺-1-羟基苯 |
| Synonyms | 6-anilinoquinoline-5,8-dione; 6-(Phenylamino)quinoline-5,8-dione; 6-ANILINO-5,8-QUINOLINEDIONE; MFCD00210756 |
| Molecular Formula | C15H10N2O2 |
| Molecular Weight | 250.25 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 446.9±45.0 °C at 760 mmHg |
| Melting Point | 184-185°C |
| Appearance | solid |
| Water Solubility | 0.1 M HCl: 1 mg/mL |
| Storage Condition | Refrigerate at 2-8°C |
| Application | LY83583 is a cell-permeable and competitive inhibitor of soluble guanylyl cyclase (sGC) with an IC50 value of 2µM [1]. |
| HTC | 2933499090 |
| MDL Number | MFCD00210756 |
| SMILES | N(c3ccccc3)C1=CC(=O)c2ncccc2C1=O |
| InChI | 1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H |
| InChI Key | GXIJYWUWLNHKNW-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/80755_1_91300_60_6.pdf |
| Use of | LY83583 is a cell-permeable and competitive inhibitor of soluble guanylate cyclase (sGC) with an IC50 value of 2 µM[1]. Properties Articles33 Name 6-anilino-5,8-quinolinedione Synonym More Synonyms LY83583 Biological Activity Description LY83583 is a cell-permeable and competitive inhibitor of soluble guanylate cyclase (sGC) with an IC50 value of 2 µM[1]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase References [1]. Mülsch A, et al. LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increases and inhibition of platelet activation. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):119-25. Chemical & Physical Properties Molecular Formula C15H10N2O2 Exact Mass 250.074234 PSA 59.06000 Index of Refraction 1.715 InChIKey GXIJYWUWLNHKNW-UHFFFAOYSA-N Safety Information Hazard Codes Xn: Harmful; Risk Phrases R40 RIDADR NONH for all modes of transport WGK Germany 2 HS Code 2933499090 Synthetic Route Total: 1 Page 5,8-QUINOLINEQUINONE CAS#:10470-83-4 CAS#:74497-02-2 CAS#:91300-60-6 Literature: Jiang, Chunhui; Wang, Shaozhong Synlett, 2009 , # 7 p. 1099 - 1102 CAS#:74497-02-2 CAS#:91300-60-6 Literature: Chemische Berichte, , vol. 17, p. 1645 5-Amino-8-hydro... CAS#:13207-66-4 CAS#:91300-60-6 Literature: Chemische Berichte, , vol. 17, p. 1645 Precursor & DownStream Precursor 2 CAS#:10470-83-4 5,8-QUINOLINEQUINONE CAS#:13207-66-4 5-Amino-8-hydro... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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