| Chemical & Physical Properties | |
|---|---|
| CAS Number | 52128-35-5 |
| Catalog No. | 2A-9079677 |
| Chinese Name | 三甲曲沙 |
| Synonyms | Trimetrexato; Trimetrexate; CI-898; Trimetrexatum; Jb-11 |
| Molecular Formula | C19H23N5O3 |
| Molecular Weight | 369.41800 |
| Density | 1.305g/cm3 |
| Boiling Point | 647ºC at 760mmHg |
| Storage Condition | 2-8℃ |
| Application | Trimetrexate is an antibiotic and mammalian dihydrofolate reductase inhibitor. |
| HTC | 2933990090 |
| PubChem ID | 13336 |
| SMILES | COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC |
| InChI | InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) |
| InChI Key | NOYPYLRCIDNJJB-UHFFFAOYSA-N |
| Use of | Trimetrexate(CI-898) is a potent competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase.IC50 value:Target: Antibiotic Trimetrexate therapy had minimal toxicity; transient neutropenia or thrombocytopenia occurred in 12 patients and mild elevation of serum aminotransferases in 4. We conclude that the combination of trimetrexate and leucovorin is safe and effective for the initial treatment of pneumocystis pneumonia in patients with AIDS and for the treatment of patients with intolerance or lack of response to standard therapies [1]. In noncomparative trials trimetrexate was effective in the treatment of P. carinii pneumonia (PCP) in patients with AIDS who were intolerant of or refractory to cotrimoxazole (trimethoprim/sulfamethoxazole) and pentamidine treatment. In these patients, 2- to 4-week survival rates of 48 to 69% were reported. In a comparative trial in the initial therapy of PCP, trimetrexate was less effective than cotrimoxazole in moderate to severe disease as evidenced by a significantly higher failure rate [2]. trimetrexate plus leucovorin was effective, albeit inferior to TMP-SMZ, for moderately severe P. carinii pneumonia but was better tolerated than TMP-SMZ [3]. Properties Name 5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine Synonym More Synonyms Trimetrexate Biological Activity Description Trimetrexate(CI-898) is a potent competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase.IC50 value:Target: Antibiotic Trimetrexate therapy had minimal toxicity; transient neutropenia or thrombocytopenia occurred in 12 patients and mild elevation of serum aminotransferases in 4. We conclude that the combination of trimetrexate and leucovorin is safe and effective for the initial treatment of pneumocystis pneumonia in patients with AIDS and for the treatment of patients with intolerance or lack of response to standard therapies [1]. In noncomparative trials trimetrexate was effective in the treatment of P. carinii pneumonia (PCP) in patients with AIDS who were intolerant of or refractory to cotrimoxazole (trimethoprim/sulfamethoxazole) and pentamidine treatment. In these patients, 2- to 4-week survival rates of 48 to 69% were reported. In a comparative trial in the initial therapy of PCP, trimetrexate was less effective than cotrimoxazole in moderate to severe disease as evidenced by a significantly higher failure rate [2]. trimetrexate plus leucovorin was effective, albeit inferior to TMP-SMZ, for moderately severe P. carinii pneumonia but was better tolerated than TMP-SMZ [3]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Allegra CJ, et al. Trimetrexate for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. N Engl J Med. 1987 Oct 15;317(16):978-85. [2]. Fulton B, et al. Trimetrexate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of Pneumocystis carinii pneumonia. Drugs. 1995 Apr;49(4):563-76. Chemical & Physical Properties Molecular Formula C19H23N5O3 Exact Mass 369.18000 PSA 117.54000 LogP 3.97590 InChIKey NOYPYLRCIDNJJB-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information HS Code 2933990090 Synthetic Route Total: 1 Page Quinazoline CAS#:253-82-7 3,4,5-Trimethox... CAS#:24313-88-0 2,4-Diamino-5-m... CAS#:18917-72-1 Trimetrexate CAS#:52128-35-5 Literature: FMC Corporation Patent: US5534518 A1, 1996 ; Precursor & DownStream Precursor 3 CAS#:253-82-7 Quinazoline CAS#:24313-88-0 3,4,5-Trimethox... CAS#:18917-72-1 2,4-Diamino-5-m... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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