CAS Number4880-88-0
Synonyms(3α,16α)-14,15-Dihydroeburnamenin-14-one; 3a,16a-Eburnamonine; vinburnine; (-)-EBURNAMONINE; (3a,16a)-Eburnamenin-14(15H)-one; Vincamone; MFCD00064309; 16-Oxoeburnane; (3a,16a)-Eburnamin-14(15H)-one; EINECS 225-490-5; cis-Vincamone
Molecular FormulaC19H22O1N2
Molecular Weight294.4
Density1.3±0.1 g/cm3
Boiling Point441.9±33.0 °C at 760 mmHg
Melting Point174-177 °C(lit.)
Appearancewhite powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4880-88-0 |
| Catalog No. | 2A-9079523 |
| Chinese Name | 长春布宁 |
| Synonyms | (3α,16α)-14,15-Dihydroeburnamenin-14-one; 3a,16a-Eburnamonine; vinburnine; (-)-EBURNAMONINE; (3a,16a)-Eburnamenin-14(15H)-one; Vincamone; MFCD00064309; 16-Oxoeburnane; (3a,16a)-Eburnamin-14(15H)-one; EINECS 225-490-5; cis-Vincamone |
| Molecular Formula | C19H22O1N2 |
| Molecular Weight | 294.4 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 441.9±33.0 °C at 760 mmHg |
| Melting Point | 174-177 °C(lit.) |
| Appearance | white powder |
| Storage Condition | Store airtight in a cool, dry warehouse. |
| Application | Vincamone is a metabolite of vinca alkaloids and vincamine and is a vasodilator. |
| HTC | 2933990090 |
| PubChem ID | 11341 |
| MDL Number | MFCD00064309 |
| SMILES | CCC12CCCN3CCc4c(n(c5ccccc45)C(=O)C1)C32 |
| InChI | InChI=1S/C19H22N2O/c1-2-19-9-5-10-20-11-8-14-13-6-3-4-7-15(13)21(16(22)12-19)17(14)18(19)20/h3-4,6-7,18H,2,5,8-12H2,1H3/t18-,19+/m1/s1 |
| InChI Key | WYJAPUKIYAZSEM-MOPGFXCFSA-N |
| MSDS | msds/79523_1_4880_88_0.pdf |
| Use of | Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator. Properties Name (-)-Eburnamonine Synonym More Synonyms Vinburnine Biological Activity Description Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease Chemical & Physical Properties Molecular Formula C19H22N2O Exact Mass 294.173218 PSA 25.24000 Index of Refraction 1.719 InChIKey WYJAPUKIYAZSEM-MOPGFXCFSA-N Storage condition -20℃ Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C19-H22-N2-O MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3852453 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 14,160,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 14,160,1978 Safety Information WGK Germany 2 RTECS YY8575570 HS Code 2933990090 Synthetic Route (1S,12bS)-1-eth... 111687-22-0 Vinburnine Literature: Node; Nagasawa; Fuji Journal of the American Chemical Society, 1987 , vol. 109, # 25 p. 7901 - 7903 Vinburnine Literature: Woods, James R.; Riofski, Mark V.; Zheng, Mary M.; O'Banion, Melissa A.; Mo, Huaping; Kirshner, Julia; Colby, David A. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5865 - 5869 (4R,5S)-3-[(2S)... 121074-25-7 Vinburnine Literature: Wee; Yu Journal of Organic Chemistry, 2001 , vol. 66, # 26 p. 8935 - 8943 Precursor & DownStream Precursor 7 CAS#:85588-92-7 (-)-methyl 1,2,... CAS#:111687-22-0 (1S,12bS)-1-eth... CAS#:1617-90-9 CAS#:121074-25-7 (4R,5S)-3-[(2S)... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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