CAS Number6893-26-1
SynonymsH-D-Glu-OH; MFCD00063112; D(-)-Glutamic acid; glutamic acid D-form; EINECS 230-000-8; δ-Glutamic acid; hydrogen D-glutamate; d-Glu; (R)-(-)-GLUTAMIC ACID; R-(-)-Glutamic acid; (2R)-2-aminopentanedioic acid; D-Glutamic acid; D(-)-Glutamicacid
Molecular FormulaHO2CCH2CH2CH(NH2)CO2H
Molecular Weight147.13
Purity≥99 (TLC)%
Density1.4±0.1 g/cm3
Boiling Point333.8±32.0 °C at 760 mmHg
Melting Point200-202 °C (subl.) (lit.)
Appearancepowder
EINECS230-000-8
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6893-26-1 |
| Catalog No. | 2A-9007928 |
| Chinese Name | D-谷氨酸 |
| Synonyms | H-D-Glu-OH; MFCD00063112; D(-)-Glutamic acid; glutamic acid D-form; EINECS 230-000-8; δ-Glutamic acid; hydrogen D-glutamate; d-Glu; (R)-(-)-GLUTAMIC ACID; R-(-)-Glutamic acid; (2R)-2-aminopentanedioic acid; D-Glutamic acid; D(-)-Glutamicacid |
| Molecular Formula | HO2CCH2CH2CH(NH2)CO2H |
| Molecular Weight | 147.13 |
| Purity | ≥99 (TLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 333.8±32.0 °C at 760 mmHg |
| Melting Point | 200-202 °C (subl.) (lit.) |
| Appearance | powder |
| Storage Condition | Room Temperature |
| Application | D-glutamic acid is the enantiomer of L-glutamic acid and is widely used in drugs and food. |
| EINECS | 230-000-8 |
| HTC | 2918990090 |
| PubChem ID | 24895031 |
| MDL Number | MFCD00063112 |
| SMILES | N[C@H](CCC(O)=O)C(O)=O |
| InChI | 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 |
| InChI Key | WHUUTDBJXJRKMK-GSVOUGTGSA-N |
| Beilstein/REAXYS | 1723800 |
| NACRES Code | NA.32 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| MSDS | msds/7928_1_6893_26_1.pdf |
| Bioactivity | D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vitro Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu) are widely found in mammals including human beings and they are now thought to be the candidates of novel physiologically active substances and/or biomarkers[1]. D-[Asp/Glu] (4 mg/mL) inhibits IgE binding (75%) to peanuts while D-Glu, D-Asp has no inhibitory effect. IgE is specific for D-[Asp/Glu] and may have the potential for removing IgE or reducing IgE binding to peanut allergens[2]. In Vivo D-glutamic acid is currently paid attention as a modulator of neuronal transmission and hormonal secretion. It is metabolized only by D-aspartate oxidase in mammals[1]. After intraperitoneal injection, L-glutamate is catabolized via a-ketoglutarate, whereas D-glutamate is converted to n-pyrrolidone carboxylic acid. Carbon 2 of both D- and L-glutamate is converted in the cecum to the methyl carbon of acetate. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid[3]. Animal Admin Rats: Male albino rats are given injections of L- or D-glutamic acid-2-C14, DL-glutamic acid-5-C14, or D-glutamic acid-5-C14. Injections by stomach tube or into the cecum are performed while the animals are under ether anesthesia. After the rats are killed, the "carcass" and liver glutamic acids are isolated, degraded, and assayed for radioactivity. "Carcass" refers to the entire animal, except liver, including the ished gastrointestinal tract[3]. References [1]. Han H, et al. Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities. J Pharm Biomed Anal. 2015 Dec 10;116:47-52. [2]. Chung SY, et al. IgE binding to peanut allergens is inhibited by combined D-aspartic and D-glutamic acids. Food Chem. 2015 Jan 1;166:248-53. [3]. Wilson W, et al. The metabolism of D- and L- glutamic acid in the rat. J Biol Chem. 1961 Feb;236:365-9. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 333.8±32.0 °C at 760 mmHg Melting Point 200-202ºC Molecular Formula C5H9NO4 Molecular Weight 147.129 Flash Point 155.7±25.1 °C Exact Mass 147.053162 PSA 100.62000 LogP -1.43 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.522 InChIKey WHUUTDBJXJRKMK-GSVOUGTGSA-N SMILES NC(CCC(=O)O)C(=O)O |
| Use of | D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods. Properties Articles189 Name D-glutamic acid Synonym More Synonyms D(-)-Glutamic acid Biological Activity Description D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vivo D-glutamic acid is currently paid attention as a modulator of neuronal transmission and hormonal secretion. It is metabolized only by D-aspartate oxidase in mammals[1]. After intraperitoneal injection, L-glutamate is catabolized via a-ketoglutarate, whereas D-glutamate is converted to n-pyrrolidone carboxylic acid. Carbon 2 of both D- and L-glutamate is converted in the cecum to the methyl carbon of acetate. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid[3]. Animal Admin Rats: Male albino rats are given injections of L- or D-glutamic acid-2-C14, DL-glutamic acid-5-C14, or D-glutamic acid-5-C14. Injections by stomach tube or into the cecum are performed while the animals are under ether anesthesia. After the rats are killed, the "carcass" and liver glutamic acids are isolated, degraded, and assayed for radioactivity. "Carcass" refers to the entire animal, except liver, including the ished gastrointestinal tract[3]. References [1]. Han H, et al. Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities. J Pharm Biomed Anal. 2015 Dec 10;116:47-52. [2]. Chung SY, et al. IgE binding to peanut allergens is inhibited by combined D-aspartic and D-glutamic acids. Food Chem. 2015 Jan 1;166:248-53. [3]. Wilson W, et al. The metabolism of D- and L- glutamic acid in the rat. J Biol Chem. 1961 Feb;236:365-9. Chemical & Physical Properties Molecular Formula C5H9NO4 Exact Mass 147.053162 PSA 100.62000 LogP -1.43 Index of Refraction 1.522 InChIKey WHUUTDBJXJRKMK-GSVOUGTGSA-N SMILES NC(CCC(=O)O)C(=O)O |
| Tax Rebate | 9.0% |
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| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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