CAS Number757239-60-4
Synonyms1-CBZ-AZETIDINE-3-CARBOXYLIC ACID METHYL ESTER; 1-[(Benzyloxy)carbonyl]-3-methyl-3-azetidinecarboxylic acid; 1-Cbz-3-azetidinecarboxylic acid methyl ester; 1-Benzyl 3-methyl 1,3-azetidinedicarboxylate; Methyl1-Cbz-azetidine-3-carboxylate; 1-BENZYL 3-METHYL AZETIDINE-1,3-DICARBOXYLATE; HT799; Azetidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester; 1,3-Azetidinedicarboxylic acid, 3-methyl-, 1-(phenylmethyl) ester; methyl 1-benzyloxycarbonyl-3-azetidinecarboxylate
Molecular FormulaC13H15NO4
Molecular Weight249.262
Density1.3±0.1 g/cm3
Boiling Point414.9±45.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 757239-60-4 |
| Catalog No. | 2A-9078202 |
| Chinese Name | 1-Cbz-氮杂环丁烷-3-甲酸甲酯 |
| Synonyms | 1-CBZ-AZETIDINE-3-CARBOXYLIC ACID METHYL ESTER; 1-[(Benzyloxy)carbonyl]-3-methyl-3-azetidinecarboxylic acid; 1-Cbz-3-azetidinecarboxylic acid methyl ester; 1-Benzyl 3-methyl 1,3-azetidinedicarboxylate; Methyl1-Cbz-azetidine-3-carboxylate; 1-BENZYL 3-METHYL AZETIDINE-1,3-DICARBOXYLATE; HT799; Azetidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester; 1,3-Azetidinedicarboxylic acid, 3-methyl-, 1-(phenylmethyl) ester; methyl 1-benzyloxycarbonyl-3-azetidinecarboxylate |
| Molecular Formula | C13H15NO4 |
| Molecular Weight | 249.262 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 414.9±45.0 °C at 760 mmHg |
| Storage Condition | room temperature, dry |
| Application | 1-Cbz-Azetidine-3-carboxylic acid methyl ester is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADC). 1-Cbz-Azetidine-3-carboxylic acid methyl ester is also a PROTAC linker |
| HTC | 2933990090 |
| InChI | InChI=1S/C13H15NO4/c1-17-12(15)11-7-14(8-11)13(16)18-9-10-5-3-2-4-6-10/h2-6,11H,7-9H2,1H3 |
| InChI Key | VMBHUIMZBSWWCN-UHFFFAOYSA-N |
| Use of | Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 Properties Name 1-O-benzyl 3-O-methyl azetidine-1,3-dicarboxylate Synonym More Synonyms Methyl 1-Cbz-azetidine-3-carboxylate Biological Activity Description Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C13H15NO4 Exact Mass 249.100113 PSA 55.84000 Index of Refraction 1.580 Safety Information HS Code 2933990090 Synthetic Route Total: 1 Page diazomethane CAS#:186581-53-3 1-benzyloxycarb... CAS#:97628-92-7 Methyl 1-Cbz-az... CAS#:757239-60-4 Methyl azetidin... CAS#:100202-39-9 Benzyl chloroformate CAS#:501-53-1 Methyl 1-Cbz-az... CAS#:757239-60-4 1-benzyloxycarb... CAS#:97628-92-7 (Trimethylsilyl... CAS#:18107-18-1 Methyl 1-Cbz-az... CAS#:757239-60-4 Precursor & DownStream Precursor 5 CAS#:97628-92-7 1-benzyloxycarb... CAS#:18107-18-1 (Trimethylsilyl... CAS#:186581-53-3 diazomethane CAS#:100202-39-9 Methyl azetidin... DownStream 2 CAS#:97628-92-7 1-benzyloxycarb... CAS#:912444-78-1 Methyl 1-Cbz-3-... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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