CAS Number199327-61-2
Synonyms7-Methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4(3H)-one; 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one; 7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(1H)-quinazolinone
Molecular FormulaC16H21N3O4
Molecular Weight319.36
Density1.3±0.1 g/cm3
Boiling Point564.4±50.0 °C at 760 mmHg
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 199327-61-2 |
| Catalog No. | 2A-9078120 |
| Chinese Name | 7-甲氧基-6-(3-吗啉-4-基丙氧基)喹唑啉-4(3H)-酮 |
| Synonyms | 7-Methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4(3H)-one; 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one; 7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(1H)-quinazolinone |
| Molecular Formula | C16H21N3O4 |
| Molecular Weight | 319.36 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 564.4±50.0 °C at 760 mmHg |
| Appearance | solid |
| Storage Condition | 2~8℃ |
| Application | Gefitinib impurity 5 is an impurity in Gefitinib. Gefitinib is a potent, orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tu |
| HTC | 2934999090 |
| PubChem ID | 15420739 |
| MDL Number | MFCD12760130 |
| SMILES | N3(CCOCC3)CCCOc1cc2c(nc[nH][c]2=O)cc1OC |
| InChI | 1S/C16H21N3O4/c1-21-14-10-13-12(16(20)18-11-17-13)9-15(14)23-6-2-3-19-4-7-22-8-5-19/h9-11H,2-8H2,1H3,(H,17,18,20) |
| InChI Key | WFUBWLXSYCFZEH-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/78120_1_199327_61_2.pdf |
| Use of | Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2]. Properties Name 7-methoxy-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-4-one Synonym More Synonyms Gefitinib impurity 5 Biological Activity Description Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54. Chemical & Physical Properties Molecular Formula C16H21N3O4 Exact Mass 319.153198 PSA 76.68000 Index of Refraction 1.611 InChIKey WFUBWLXSYCFZEH-UHFFFAOYSA-N Storage condition 2~8℃ Safety Information Hazard Codes Xi HS Code 2934999090 Precursor & DownStream Precursor 8 CAS#:184475-35-2 CAS#:246512-44-7 Gefitinib impurity 2 CAS#:64-18-6 Formic Acid CAS#:77287-34-4 (Z)-Methanimidi... DownStream 2 CAS#:847949-49-9 O-Desmethyl gef... CAS#:184475-35-2 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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