CAS Number67-73-2
SynonymsEINECS 200-668-5; 6a,9a-Difluoro-16a-hydroxyprednisolone 16,17-acetonide; MFCD00010525; 6a,9a-Difluoro-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione; 6α,9α-Difluoro-11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione; Fluocinolone Acetonide; Fluocinolone (Acetonide)
Molecular FormulaC24H30F2O6
Molecular Weight452.49
Purity97%
Density1.4±0.1 g/cm3
Boiling Point578.5±50.0 °C at 760 mmHg
Melting Point267-269 °C (lit.)
EINECS200-668-5
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 67-73-2 |
| Catalog No. | 2A-9007809 |
| Chinese Name | 醋酸氟轻松 |
| Synonyms | EINECS 200-668-5; 6a,9a-Difluoro-16a-hydroxyprednisolone 16,17-acetonide; MFCD00010525; 6a,9a-Difluoro-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione; 6α,9α-Difluoro-11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione; Fluocinolone Acetonide; Fluocinolone (Acetonide) |
| Molecular Formula | C24H30F2O6 |
| Molecular Weight | 452.49 |
| Purity | 97 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 578.5±50.0 °C at 760 mmHg |
| Melting Point | 267-269 °C (lit.) |
| Storage Condition | Refrigerator |
| Application | Fluocinolone Acetonide is a glucocorticoid derivative that can act on various skin diseases. |
| EINECS | 200-668-5 |
| HTC | 2937210000 |
| PubChem ID | 329823371 |
| MDL Number | MFCD00010525 |
| SMILES | CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO |
| InChI | 1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1 |
| InChI Key | FEBLZLNTKCEFIT-VSXGLTOVSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/7809_1_67_73_2.pdf |
| Bioactivity | Fluocinolone Acetonide is a glucocorticoid derivative used topically in the treatment of various skin disorders.Target: Glucocorticoid ReceptorFluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A typical dosage strength used in dermatology is 0.01-0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin. The Glucocorticoid Receptor(GR) binding affinity (IC50) for Fluocinolone Acetonide(FA) was 2.0 nM, respectively. The values is similar to the GR transactivation EC50 of 0.7 nM for FA, respectively [1, 2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. http://en.wikipedia.org/wiki/Fluocinolone_acetonide [2]. Nehme, A., et al., Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics, 2009. 2: p. 58. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 578.5±50.0 °C at 760 mmHg Melting Point 267-269 °C(lit.) Molecular Formula C24H30F2O6 Molecular Weight 452.488 Flash Point 303.7±30.1 °C Exact Mass 452.201050 PSA 93.06000 LogP 2.24 Vapour Pressure 0.0±3.6 mmHg at 25°C Index of Refraction 1.577 InChIKey FEBLZLNTKCEFIT-VSXGLTOVSA-N SMILES CC1(C)OC2CC3C4CC(F)C5=CC(=O)C=CC5(C)C4(F)C(O)CC3(C)C2(C(=O)CO)O1 Storage condition Refrigerator |
| Use of | Fluocinolone Acetonide is a glucocorticoid derivative used topically in the treatment of various skin disorders.Target: Glucocorticoid ReceptorFluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A typical dosage strength used in dermatology is 0.01-0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin. The Glucocorticoid Receptor(GR) binding affinity (IC50) for Fluocinolone Acetonide(FA) was 2.0 nM, respectively. The values is similar to the GR transactivation EC50 of 0.7 nM for FA, respectively [1, 2]. Properties Articles47 Name fluocinolone acetonide Synonym More Synonyms Fluocinolone Acetonide Biological Activity Description Fluocinolone Acetonide is a glucocorticoid derivative used topically in the treatment of various skin disorders.Target: Glucocorticoid ReceptorFluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A typical dosage strength used in dermatology is 0.01-0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin. The Glucocorticoid Receptor(GR) binding affinity (IC50) for Fluocinolone Acetonide(FA) was 2.0 nM, respectively. The values is similar to the GR transactivation EC50 of 0.7 nM for FA, respectively [1, 2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. http://en.wikipedia.org/wiki/Fluocinolone_acetonide Chemical & Physical Properties Molecular Formula C24H30F2O6 Exact Mass 452.201050 PSA 93.06000 Index of Refraction 1.577 InChIKey FEBLZLNTKCEFIT-VSXGLTOVSA-N Storage condition Refrigerator |
| Transport Info | Product Name: Fluocinolone Acetonide |
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