CAS Number74209-34-0
Synonyms3-bromo-7-nitro-2H-indazole; 3-Bromo-7-nitro-1H-indazole; MFCD00159910
Molecular FormulaC7H4BrN3O2
Molecular Weight267.08
Purity≥98.0 (HPLC)%
Density2.0±0.1 g/cm3
Boiling Point437.3±25.0 °C at 760 mmHg
Melting Point175-185 °C
Appearancepowder
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 74209-34-0 |
| Catalog No. | 2A-9078007 |
| Chinese Name | 3-溴-7-硝基吲哚 |
| Synonyms | 3-bromo-7-nitro-2H-indazole; 3-Bromo-7-nitro-1H-indazole; MFCD00159910 |
| Molecular Formula | C7H4BrN3O2 |
| Molecular Weight | 267.08 |
| Purity | ≥98.0 (HPLC) |
| Density | 2.0±0.1 g/cm3 |
| Boiling Point | 437.3±25.0 °C at 760 mmHg |
| Melting Point | 175-185 °C |
| Appearance | powder |
| Water Solubility | ethanol: 25 mg/mL |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | 3-Bromo-7-nitroindazole is a potent, selective neuronal nitric oxide synthase (nNOS) inhibitor with greater potency than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects |
| HTC | 2933990090 |
| PubChem ID | 329764685 |
| MDL Number | MFCD00137823 |
| SMILES | OC(=O)c1cc2cc(Br)ccc2cc1O |
| InChI | 1S/C11H7BrO3/c12-8-2-1-6-5-10(13)9(11(14)15)4-7(6)3-8/h1-5,13H,(H,14,15) |
| InChI Key | XZWXQSGFZHRDNB-UHFFFAOYSA-N |
| Beilstein/REAXYS | 2372925 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | transportation |
| MSDS | msds/78007_1_74209_34_0.pdf |
| Bioactivity | 3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain[1]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Neurological Disease Target nNOS[1] References [1]. Gocmez SS, et al. The effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 7-nitroindazoleon spatial learning and memory in rats. Pharmacol Biochem Behav. 2015 Apr;131:19-25. Chemical & Physical Properties Density 2.0±0.1 g/cm3 Boiling Point 437.3±25.0 °C at 760 mmHg Melting Point 175-185 °C Molecular Formula C7H4BrN3O2 Molecular Weight 242.030 Flash Point 218.3±23.2 °C Exact Mass 240.948685 PSA 74.50000 LogP 2.52 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.764 InChIKey NFSTZPMYAZRZPC-UHFFFAOYSA-N SMILES O=[N+]([O-])c1cccc2c(Br)[nH]nc12 Storage condition 2-8°C Water Solubility ethanol: 25 mg/mL |
| Use of | 3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain[1]. Properties Name 3-Bromo-7-nitro-1H-indazole Synonym More Synonyms 3-Bromo-7-nitro-1H-indazole Biological Activity Description 3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain[1]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Neurological Disease References [1]. Gocmez SS, et al. The effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 7-nitroindazoleon spatial learning and memory in rats. Pharmacol Biochem Behav. 2015 Apr;131:19-25. Chemical & Physical Properties Molecular Formula C7H4BrN3O2 Exact Mass 240.948685 PSA 74.50000 Index of Refraction 1.764 InChIKey NFSTZPMYAZRZPC-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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