CAS Number165377-44-6
Synonyms1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine,dihydrochloride; 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazinedihydrochloride; Piperazine, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)-, hydrochloride (1:2); 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride; SA-4503; SA4503 2HCl; SA4503 (dihydrochloride)
Molecular FormulaC23H34O2N2Cl2
Molecular Weight441.44
Boiling Point499.2ºC at 760 mmHg
AppearanceWhite to beige powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 165377-44-6 |
| Catalog No. | 2A-9077875 |
| Chinese Name | 1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐 |
| Synonyms | 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine,dihydrochloride; 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazinedihydrochloride; Piperazine, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)-, hydrochloride (1:2); 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride; SA-4503; SA4503 2HCl; SA4503 (dihydrochloride) |
| Molecular Formula | C23H34O2N2Cl2 |
| Molecular Weight | 441.44 |
| Boiling Point | 499.2ºC at 760 mmHg |
| Appearance | White to beige powder |
| Storage Condition | 2-8°C, sealed and dry away from light and moisture |
| Application | Cutamesine dihydrochloride (SA4503 dihydrochloride) is a potent Sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig meninges. |
| HTC | 2933599090 |
| PubChem ID | 14930525 |
| MDL Number | MFCD00939308 |
| SMILES | COc1ccc(CCN2CCN(CCCc3ccccc3)CC2)cc1OC.Cl.Cl |
| InChI | InChI=1S/C23H32N2O2.2ClH/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20;;/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3;2*1H |
| InChI Key | XWOXAKBQEMQMFH-UHFFFAOYSA-N |
| MSDS | msds/77875_1_165377_44_6.pdf |
| Use of | Cutamesine dihydrochloride (SA4503 dihydrochloride) is a potent Sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Properties Name 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride Synonym More Synonyms SA 4503 dihydrochloride Biological Activity Description Cutamesine dihydrochloride (SA4503 dihydrochloride) is a potent Sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Related Catalog Signaling Pathways >> GPCR/G Protein >> Sigma Receptor Research Areas >> Neurological Disease IC50: 17.4 nM (σ1receptor, guinea pig brain membranes)[1] In Vivo Cutamesine extends the survival time in the SOD1G93A mice[2]. References [1]. Lever JR, et al. Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59(6):350-8. [2]. Tuerxun T, et al. SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. Neurosci Lett. 2010 Jan 29;469(3):303-8. Chemical & Physical Properties Exact Mass 440.199738 PSA 24.94000 LogP 4.97650 InChIKey XWOXAKBQEMQMFH-UHFFFAOYSA-N Safety Information HS Code 2933599090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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