CAS Number294-90-6
SynonymsTetraaza-12-crown-4; T-12-M DM GM JMTJ; Cyclen; 1,4,7,10-tetrazacyclododecane; MFCD00066281; 1,4,7,10-Tetraazacyclododecane; 5-26-11-00023 (Beilstein Handbook Reference); [12]aneN4; 1,4,7,12-tetraazacyclodedecane; EINECS 202-928-3
Molecular FormulaC8H20N4
Molecular Weight172.27
Purity97%
Density0.9±0.1 g/cm3
Boiling Point283.8±8.0 °C at 760 mmHg
Melting Point110-113 °C (lit.)
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 294-90-6 |
| Catalog No. | 2A-9000776 |
| Chinese Name | 轮环藤宁 |
| Synonyms | Tetraaza-12-crown-4; T-12-M DM GM JMTJ; Cyclen; 1,4,7,10-tetrazacyclododecane; MFCD00066281; 1,4,7,10-Tetraazacyclododecane; 5-26-11-00023 (Beilstein Handbook Reference); [12]aneN4; 1,4,7,12-tetraazacyclodedecane; EINECS 202-928-3 |
| Molecular Formula | C8H20N4 |
| Molecular Weight | 172.27 |
| Purity | 97 |
| Density | 0.9±0.1 g/cm3 |
| Boiling Point | 283.8±8.0 °C at 760 mmHg |
| Melting Point | 110-113 °C (lit.) |
| Appearance | solid |
| Storage Condition | Refrigerator |
| Packaging | I; II; III |
| Application | Cyclen is an analogue of azacrown ether, a precursor substance for the preparation of magnetic resonance contrast agents, and an intermediate for the preparation of effective macrocyclic chelates. |
| HTC | 2933990090 |
| PubChem ID | 24860658 |
| MDL Number | MFCD00066281 |
| SMILES | C1CNCCNCCNCCN1 |
| InChI | 1S/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2 |
| InChI Key | QBPPRVHXOZRESW-UHFFFAOYSA-N |
| Beilstein/REAXYS | 606114 |
| NACRES Code | NA.23 |
| UNSPSC | 12162002 |
| Hazard Symbols | Transport |
| Risk Codes | R36/38 |
| Safety Description | S26;S36 |
| MSDS | msds/776_1_294_90_6.pdf |
| Bioactivity | Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates[1]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Rashid HU, et al. Cyclen-based Gd3+ complexes as MRI contrast agents: Relaxivity enhancement and ligand design. Bioorg Med Chem. 2016 Nov 15;24(22):5663-5684. Chemical & Physical Properties Density 0.9±0.1 g/cm3 Boiling Point 283.8±8.0 °C at 760 mmHg Melting Point 110-113 °C(lit.) Molecular Formula C8H20N4 Molecular Weight 172.27 Flash Point 129.5±13.5 °C Exact Mass 172.168793 PSA 48.12000 LogP -2.34 Vapour Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.424 InChIKey QBPPRVHXOZRESW-UHFFFAOYSA-N SMILES C1CNCCNCCNCCN1 Storage condition Refrigerator |
| Use of | Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates[1]. Properties Articles31 Name 1,4,7,10-tetraazacyclododecane Synonym More Synonyms Cyclen Biological Activity Description Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates[1]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Rashid HU, et al. Cyclen-based Gd3+ complexes as MRI contrast agents: Relaxivity enhancement and ligand design. Bioorg Med Chem. 2016 Nov 15;24(22):5663-5684. Chemical & Physical Properties Molecular Formula C8H20N4 Exact Mass 172.168793 PSA 48.12000 LogP -2.34 Index of Refraction 1.424 InChIKey QBPPRVHXOZRESW-UHFFFAOYSA-N Storage condition Refrigerator |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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