| Chemical & Physical Properties | |
|---|---|
| CAS Number | 25222-43-9 |
| Catalog No. | 2A-9077570 |
| Chinese Name | 1H-吡唑-4-甲醇 |
| Synonyms | 1H-Pyrazole-4-methanol; 1H-Pyrazol-4-ylmethanol; pyrazol-4-ylmethan-1-ol; 4-Hydroxymethyl-pyrazol |
| Molecular Formula | C4H6N2O |
| Molecular Weight | 98.10 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 326.8±17.0 °C at 760 mmHg |
| Appearance | solid |
| Storage Condition | room temperature, dry |
| Application | 4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876). Fomepizole is a competitive alcohol dehydrogenase inhibitor. |
| HTC | 2933199090 |
| PubChem ID | 329790105 |
| MDL Number | MFCD06797673 |
| SMILES | OCc1cn[nH]c1 |
| InChI | 1S/C4H6N2O/c7-3-4-1-5-6-2-4/h1-2,7H,3H2,(H,5,6) |
| InChI Key | JRMKJOOJKCAEJK-UHFFFAOYSA-N |
| NACRES Code | NA.21 |
| UNSPSC | 12352200 |
| Use of | 4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876). Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase[1]. Properties Name 1H-pyrazol-4-ylmethanol Synonym More Synonyms 4-Hydroxymethylpyrazole Biological Activity Description 4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876). Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase[1]. Related Catalog Research Areas >> Others Human Endogenous Metabolite References [1]. R Blomstrand, et al. Pyrazoles as Inhibitors of Alcohol Oxidation and as Important Tools in Alcohol Research: An Approach to Therapy Against Methanol Poisoning. Proc Natl Acad Sci U S A . 1979 Jul;76(7):3499-503. Chemical & Physical Properties Molecular Formula C4H6N2O Exact Mass 98.048012 PSA 48.91000 LogP -0.87 Index of Refraction 1.590 InChIKey JRMKJOOJKCAEJK-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2933199090 Synthetic Route Total: 1 Page Ethyl 4-pyrazol... CAS#:37622-90-5 4-Hydroxymethyl... CAS#:25222-43-9 (1-BENZYL-1H-PY... CAS#:70817-17-3 4-Hydroxymethyl... CAS#:25222-43-9 Literature: Journal of the American Chemical Society, , vol. 71, p. 4000 diazomethane CAS#:186581-53-3 Diethyl ether CAS#:60-29-7 Propargyl alcohol CAS#:107-19-7 4-Hydroxymethyl... CAS#:25222-43-9 Literature: Journal of the American Chemical Society, , vol. 71, p. 4000 Precursor & DownStream Precursor 5 CAS#:37622-90-5 Ethyl 4-pyrazol... CAS#:70817-17-3 (1-BENZYL-1H-PY... CAS#:186581-53-3 diazomethane CAS#:60-29-7 Diethyl ether DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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