CAS Number15180-02-6
Synonymsamfonelic acid; 7-Benzyl-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; Amfonelinsaeure; 7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridin-3-carbonsaeure; 7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid; 1-Ethyl-1,4-dihydro-4-oxo-7-(phenylmethyl)-1,8-naphthyridine-3-carboxylic Acid
Molecular FormulaC18H16N2O3
Molecular Weight308.33
Density1.3±0.1 g/cm3
Boiling Point499.3±45.0 °C at 760 mmHg
Appearanceyellow powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 15180-02-6 |
| Catalog No. | 2A-9077114 |
| Chinese Name | 安福萘酸 |
| Synonyms | amfonelic acid; 7-Benzyl-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; Amfonelinsaeure; 7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridin-3-carbonsaeure; 7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid; 1-Ethyl-1,4-dihydro-4-oxo-7-(phenylmethyl)-1,8-naphthyridine-3-carboxylic Acid |
| Molecular Formula | C18H16N2O3 |
| Molecular Weight | 308.33 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 499.3±45.0 °C at 760 mmHg |
| Appearance | yellow powder |
| Storage Condition | room temperature |
| Application | WIN-25978 is a highly selective dopamine reuptake inhibitor. Tramethane interferes with in vitro neuronal uptake of norepinephrine in the rat iris but does not alter norepinephrine or dopamine concent |
| HTC | 2933990090 |
| PubChem ID | 5106497 |
| SMILES | CCn1cc(C(=O)O)c(=O)c2ccc(Cc3ccccc3)nc21 |
| InChI | InChI=1S/C18H16N2O3/c1-2-20-11-15(18(22)23)16(21)14-9-8-13(19-17(14)20)10-12-6-4-3-5-7-12/h3-9,11H,2,10H2,1H3,(H,22,23) |
| InChI Key | WHHHJDGNBVQNAU-UHFFFAOYSA-N |
| Use of | Amfonelic acid (WIN-25978) is a highly selective dopamine reuptake inhibitor. Amfonelic acid interferes with the in vitro neuronal uptake of norepinephrine in the iris of rats, but does not alter the concentrations of norepinephrine or dopamine in the whole mouse brain. Amfonelic acid can be used as a pharmacological tool to study the brain reward system, dopamine pathway and dopamine transporter[1]. Properties Name 7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid Synonym More Synonyms amfonelic acid Biological Activity Description Amfonelic acid (WIN-25978) is a highly selective dopamine reuptake inhibitor. Amfonelic acid interferes with the in vitro neuronal uptake of norepinephrine in the iris of rats, but does not alter the concentrations of norepinephrine or dopamine in the whole mouse brain. Amfonelic acid can be used as a pharmacological tool to study the brain reward system, dopamine pathway and dopamine transporter[1]. Related Catalog Research Areas >> Neurological Disease References [1]. Aceto MD, et al. Pharmacologic properties and mechanism of action of amfonelic acid. Eur J Pharmacol. 1970;10(3):344-54. Chemical & Physical Properties Molecular Formula C18H16N2O3 Exact Mass 308.116089 PSA 72.19000 Index of Refraction 1.630 InChIKey WHHHJDGNBVQNAU-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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