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Ethacridine lactate structure, CAS 1837-57-6

Ethacridine lactate

CAS Number1837-57-6

SynonymsEthacridine Lactate; RIVANOL; rivinol; 2-Hydroxypropanoic acid - 7-ethoxy-3,9-acridinediamine (1:1); 7-ethoxy-acridine-3,9-diyldiamine,DL lactate; rimaon; MFCD00013149; 2-ethoxy-6,9-diaminoacridine lactate; UNII:7T7T2I9823; flavitrol; EINECS 217-408-1; ETHODIN; TCMDC-123983; ACRYNOL; metifex; 2-Hydroxypropanoic acid - 7-ethoxyacridine-3,9-diamine (1:1); Vucine; ACRINOL; Ethacridine (lactate)

Molecular FormulaC18H21N3O4

Molecular Weight343.386

Purity99%

Density

Boiling Point270 °C(lit.)

Melting Point62-67 °C(lit.)

Flash Point

Appearance

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9007686 Purity: 99%
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Quality Control of [ 1837-57-6 ] Purity: 99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number1837-57-6
Catalog No.2A-9007686
Chinese Name乳酸依沙吖啶
SynonymsEthacridine Lactate; RIVANOL; rivinol; 2-Hydroxypropanoic acid - 7-ethoxy-3,9-acridinediamine (1:1); 7-ethoxy-acridine-3,9-diyldiamine,DL lactate; rimaon; MFCD00013149; 2-ethoxy-6,9-diaminoacridine lactate; UNII:7T7T2I9823; flavitrol; EINECS 217-408-1; ETHODIN; TCMDC-123983; ACRYNOL; metifex; 2-Hydroxypropanoic acid - 7-ethoxyacridine-3,9-diamine (1:1); Vucine; ACRINOL; Ethacridine (lactate)
Molecular FormulaC18H21N3O4
Molecular Weight343.386
Purity99
Boiling Point270 °C(lit.)
Melting Point62-67 °C(lit.)
Water Solubilitysoluble
Storage ConditionKeep the receptacle sealed, stored in a cool, dry
ApplicationEthacridine lactate is a poly(ADP-ribose) glycosyl hydrolase (PARG) inhibitor.
HTC2933990090
MDL NumberMFCD00013149
SMILESCC(O)C(=O)O.CCOc1ccc2nc3cc(N)ccc3c(N)c2c1
InChIInChI=1S/C15H15N3O.C3H6O3/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13;1-2(4)3(5)6/h3-8H,2,16H2,1H3,(H2,17,18);2,4H,1H3,(H,5,6)
InChI KeyIYLLULUTZPKQBW-UHFFFAOYSA-N
MSDSmsds/7686_1_1837_57_6.pdf
BioactivityEthacridine lactate is a poly(ADP-ribose) glycohydrolase (PARG) inhibitor. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Target PARG[1] In Vitro Ethacridine lactate is effective against mostly gram-positive species like Streptococci and Staphylococci and ineffective against gram-negative(P seudomonas aeruginosa)[1]. Ethacridine Lactate is a safe abortifacient with about 80% success and hardly any side effects[2]. In Vivo The incidence of retained placenta is 16%. The extra-amniotic injection is a technically simple procedure and can be carried out even between 13-15 weeks of pregnancy when intraamniotic injection is difficult. Its bactericidal properties minimize the danger of post-abortal infection. It can be used in certain medical conditions like hypertension, bronchial asthma where hypertonic saline and prostaglandin are contraindi-cated[2]. Ethacridine lactate performs better than other instillation abortion methods and it is a safe and effective method. Ethacridine lactate induces successful abortion in 92.8% of cases which is much higher than that found in the literature (about 82%). Abortion failure occurrs in the other 4 cases because of transverse lie of fetus, cervical dystocia, and uterine inertia[2]. References [1]. Rotin LE, et al. Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells. Haematologica. 2016 Nov;101(11):e449-e453. [2]. Purandare VN, et al. The place of ethacridine lactate for mid-trimester M.T.P. (Multicentric study). J Postgrad Med. 1977 Apr;23(2):77-83. [3]. Gupta S, et al. Ethacridine lactate -- a safe and effective drug for termination of pregnancy. Indian J Matern Child Health. 1993;4(2):59-61. Chemical & Physical Properties Boiling Point 270 °C(lit.) Melting Point 62-67 °C(lit.) Molecular Formula C18H21N3O4 Molecular Weight 343.377 Flash Point 143 °C Exact Mass 343.153198 PSA 131.69000 LogP 3.56530 Vapour Pressure 4.72E-11mmHg at 25°C InChIKey IYLLULUTZPKQBW-UHFFFAOYSA-N SMILES CC(O)C(=O)O.CCOc1ccc2nc3cc(N)ccc3c(N)c2c1 Water Solubility soluble
Use ofEthacridine lactate is a poly(ADP-ribose) glycohydrolase (PARG) inhibitor. Properties Name 6,9-diamino-2-ethoxyacridine lactate Synonym More Synonyms Ethacridine lactate Biological Activity Description Ethacridine lactate is a poly(ADP-ribose) glycohydrolase (PARG) inhibitor. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection In Vitro Ethacridine lactate is effective against mostly gram-positive species like Streptococci and Staphylococci and ineffective against gram-negative(P seudomonas aeruginosa)[1]. Ethacridine Lactate is a safe abortifacient with about 80% success and hardly any side effects[2]. References [1]. Rotin LE, et al. Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells. Haematologica. 2016 Nov;101(11):e449-e453. [2]. Purandare VN, et al. The place of ethacridine lactate for mid-trimester M.T.P. (Multicentric study). J Postgrad Med. 1977 Apr;23(2):77-83. [3]. Gupta S, et al. Ethacridine lactate -- a safe and effective drug for termination of pregnancy. Indian J Matern Child Health. 1993;4(2):59-61. Chemical & Physical Properties Molecular Formula C18H21N3O4 Exact Mass 343.153198 PSA 131.69000 LogP 3.56530 InChIKey IYLLULUTZPKQBW-UHFFFAOYSA-N Water Solubility soluble
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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