CAS Number148244-82-0
Synonyms(2R,3R)-4-(β-D-Glucopyranosyloxy)-2,3-bis(4-hydroxy-3-methoxybenzyl)butyl β-D-glucopyranoside; SecoisolariciresinolDiglucoside; Flaxseed Extract; Secoisolariciresinol Diglucosi; Secoisolariciresinol diglucoside
Molecular FormulaC32H50O18
Molecular Weight686.70
Purity≥97 (HPLC)%
Density1.5±0.1 g/cm3
Boiling Point989.2±65.0 °C at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 148244-82-0 |
| Catalog No. | 2A-9076738 |
| Chinese Name | 亚麻木酚素 |
| Synonyms | (2R,3R)-4-(β-D-Glucopyranosyloxy)-2,3-bis(4-hydroxy-3-methoxybenzyl)butyl β-D-glucopyranoside; SecoisolariciresinolDiglucoside; Flaxseed Extract; Secoisolariciresinol Diglucosi; Secoisolariciresinol diglucoside |
| Molecular Formula | C32H50O18 |
| Molecular Weight | 686.70 |
| Purity | ≥97 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 989.2±65.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | 2-8°C |
| Application | seco-Isolariciresinol Diglucoside is a synthetic lignan. Derived from natural plant flaxseed. Acts on macrophages to reduce NLRP3 expression and NF-κB activation. seco-Isolariciresinol Diglucoside als |
| HTC | 2932999099 |
| PubChem ID | 14888459 |
| SMILES | O3[C@H]([C@@H]([C@H]([C@@H]([C@H]3CO)O)O)O)O.O(C)c1c(ccc(c1)C[C@H]([C@H](CO)Cc2cc(c(cc2)O)OC)CO)O |
| InChI | 1S/C20H26O6.C6H12O6/c1-25-19-9-13(3-5-17(19)23)7-15(11-21)16(12-22)8-14-4-6-18(24)20(10-14)26-2;7-1-2-3(8)4(9)5(10)6(11)12-2/h3-6,9-10,15-16,21-24H,7-8,11-12H2,1-2H3;2-11H,1H2/t15-,16-;2-,3-,4+,5-,6-/m01/s1 |
| InChI Key | MJYQFWSXKFLTAY-OVEQLNGDSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352205 |
| Use of | seco-Isolariciresinol Diglucoside, a synthetic lignin, which is derived from the natural plant flaxseed. seco-Isolariciresinol Diglucoside reduces asbestos-induced NLRP3 expression, and NF-κB activation in macrophages (MF). seco-Isolariciresinol Diglucoside also activates Nrf2. Properties Articles23 Name Seco-isolariciresinol diglucoside Synonym More Synonyms Secoisolariciresinol Diglucoside Biological Activity Description seco-Isolariciresinol Diglucoside, a synthetic lignin, which is derived from the natural plant flaxseed. seco-Isolariciresinol Diglucoside reduces asbestos-induced NLRP3 expression, and NF-κB activation in macrophages (MF). seco-Isolariciresinol Diglucoside also activates Nrf2. Related Catalog Signaling Pathways >> NF-κB >> Keap1-Nrf2 Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Infection Natural Products >> Phenylpropanoids In Vitro seco-Isolariciresinol Diglucoside (LGM2605) is a nontoxic lignan with anti-inflammatory and antioxidant properties and is evaluated for protection from asbestos in murine peritoneal macrophages (MF). seco-Isolariciresinol Diglucoside significantly reduces NLRP3 ranging from 40 to 81%, IL-1β by 89-96%, and TNFα by 67-78%, as well as activated NF-κB by 48-49% while decreasing levels of nitrates/nitrites by 85-93%. seco-Isolariciresinol Diglucoside reduces asbestos-induced NLRP3 expression, proinflammatory cytokine release, NF-κB activation, and nitrosative stress in macrophages (MF) supporting its possible use in preventing the asbestos-induced inflammatory cascade leading to malignancy. seco-Isolariciresinol Diglucoside inhibits NF-κB expression and prevents asbestos-induced iNOS expression and nitric oxide production by murine peritoneal macrophages. seco-Isolariciresinol Diglucoside activates Nrf2 and induces the expression of cellular antioxidant and detoxification enzymes[1]. References [1]. Pietrofesa RA, et al. The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages. Oxid Med Cell Longev. 2017;2017:7395238. Chemical & Physical Properties Molecular Formula C32H50O18 PSA 257.68000 LogP -2.79 Index of Refraction 1.655 InChIKey SBVBJPHMDABKJV-UHFFFAOYSA-N Safety Information RIDADR NONH for all modes of transport HS Code 2932999099 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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