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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > 3,5-Bis(4-Nitrophenoxy)benzoicacid
3,5-Bis(4-Nitrophenoxy)benzoicacid structure, CAS 173550-33-9

3,5-Bis(4-Nitrophenoxy)benzoicacid

CAS Number173550-33-9

SynonymsMFCD02093450; 3,5-BIS(4-NITROPHENOXY)BENZOIC ACID

Molecular FormulaC19H12N2O8

Molecular Weight396.30700

Purity

Density1.485g/cm3

Boiling Point577.655ºC at 760 mmHg

Melting Point232 °C

Flash Point

AppearanceSolid;Light orange to Yellow to Green powder to crystal

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Cat. No.: 2A-9076369 Purity:
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Quality Control of [ 173550-33-9 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number173550-33-9
Catalog No.2A-9076369
Chinese Name3,5-双(4-硝基苯氧基)苯甲酸
SynonymsMFCD02093450; 3,5-BIS(4-NITROPHENOXY)BENZOIC ACID
Molecular FormulaC19H12N2O8
Molecular Weight396.30700
Density1.485g/cm3
Boiling Point577.655ºC at 760 mmHg
Melting Point232 °C
AppearanceSolid;Light orange to Yellow to Green powder to crystal
Storage Conditionroom temperature, dry
Application3,5-bis(4-nitrophenoxy)benzoic acid is a gamma-secretase inhibitor. 3,5-bis(4-nitrophenoxy)benzoic acid resulted in reduced release levels of aβ42 and notch-1 aβ-like peptide 25 (Nβ25). 3,5-bis(4-nitr
HTC2918990090
PubChem ID26758492
SMILESO=C(O)c1cc(Oc2ccc([N+](=O)[O-])cc2)cc(Oc2ccc([N+](=O)[O-])cc2)c1
InChIInChI=1S/C19H12N2O8/c22-19(23)12-9-17(28-15-5-1-13(2-6-15)20(24)25)11-18(10-12)29-16-7-3-14(4-8-16)21(26)27/h1-11H,(H,22,23)
InChI KeyJOSXKPZXMVHRKU-UHFFFAOYSA-N
Bioactivity3,5-Bis(4-nitrophenoxy)benzoic acid is an inhibitor of γ-secretase. 3,5-Bis(4-nitrophenoxy)benzoic acid causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). 3,5-Bis(4-nitrophenoxy)benzoic acid, as a marker for fetal hypothyroidism, is a 3,3'-diiodothyronine sulfate (T2S) cross-reactive material in maternal serum[1]. Related Catalog Research Areas >> Metabolic Disease References [1]. Wu SY, et al. Compound W, a 3,3'-diiodothyronine sulfate cross-reactive substance in serum from pregnant women--a potential marker for fetal thyroid function. Pediatr Res. 2007;61(3):307-312. [2]. Ran Y, et al. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors. PLoS One. 2015;10(6):e0128619. Published 2015 Jun 5. [3]. Greife A, et al. Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer. 2014;14:628. Published 2014 Aug 29. Chemical & Physical Properties Density 1.485g/cm3 Boiling Point 577.655ºC at 760 mmHg Melting Point 232 °C Molecular Formula C19H12N2O8 Molecular Weight 396.30700 Flash Point 303.155ºC Exact Mass 396.05900 PSA 147.40000 LogP 5.83220 Vapour Pressure 0mmHg at 25°C Index of Refraction 1.666 InChIKey JOSXKPZXMVHRKU-UHFFFAOYSA-N SMILES O=C(O)c1cc(Oc2ccc([N+](=O)[O-])cc2)cc(Oc2ccc([N+](=O)[O-])cc2)c1
Use of3,5-Bis(4-nitrophenoxy)benzoic acid is an inhibitor of γ-secretase. 3,5-Bis(4-nitrophenoxy)benzoic acid causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). 3,5-Bis(4-nitrophenoxy)benzoic acid, as a marker for fetal hypothyroidism, is a 3,3'-diiodothyronine sulfate (T2S) cross-reactive material in maternal serum[1]. Properties Name 3,5-Bis(4-nitrophenoxy)benzoic Acid Synonym More Synonyms 3,5-bis-(4-Nitrophenoxy)benzoic acid Biological Activity Description 3,5-Bis(4-nitrophenoxy)benzoic acid is an inhibitor of γ-secretase. 3,5-Bis(4-nitrophenoxy)benzoic acid causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). 3,5-Bis(4-nitrophenoxy)benzoic acid, as a marker for fetal hypothyroidism, is a 3,3'-diiodothyronine sulfate (T2S) cross-reactive material in maternal serum[1]. Related Catalog Research Areas >> Metabolic Disease References [1]. Wu SY, et al. Compound W, a 3,3'-diiodothyronine sulfate cross-reactive substance in serum from pregnant women--a potential marker for fetal thyroid function. Pediatr Res. 2007;61(3):307-312. [2]. Ran Y, et al. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors. PLoS One. 2015;10(6):e0128619. Published 2015 Jun 5. [3]. Greife A, et al. Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer. 2014;14:628. Published 2014 Aug 29. Chemical & Physical Properties Molecular Formula C19H12N2O8 Exact Mass 396.05900 PSA 147.40000 LogP 5.83220 Index of Refraction 1.666 InChIKey JOSXKPZXMVHRKU-UHFFFAOYSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 30.0%
Transport InfoProduct name: Purity: 99.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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