![6,7-Dimethoxy-4-[N-(3-chlorophenyl)amino]quinazolinehydrochloride structure, CAS 170449-18-0](/structures/80000/75883_1_170449_18_0.png)
CAS Number170449-18-0
SynonymsN-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine hydrochloride (1:1); 6,7-Dimethoxy-4-[N-(3-chlorophenyl)amino]quinazoline hydrochloride; N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride (1:1); 4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-, hydrochloride (1:1); N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine,hydrochloride; 6,7-Dimethoxy-4-[N-(3-chlorophenyl)amino]quinazolinehydrochloride
Molecular FormulaC16H15O2N3Cl2
Molecular Weight352.22
Density1.337g/cm3
Boiling Point458.5ºC at 760mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 170449-18-0 |
| Catalog No. | 2A-9075883 |
| Chinese Name | N-(3-氯苯基)-6,7-二甲氧基-4-喹唑啉胺盐酸盐 |
| Synonyms | N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine hydrochloride (1:1); 6,7-Dimethoxy-4-[N-(3-chlorophenyl)amino]quinazoline hydrochloride; N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride (1:1); 4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-, hydrochloride (1:1); N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine,hydrochloride; 6,7-Dimethoxy-4-[N-(3-chlorophenyl)amino]quinazolinehydrochloride |
| Molecular Formula | C16H15O2N3Cl2 |
| Molecular Weight | 352.22 |
| Density | 1.337g/cm3 |
| Boiling Point | 458.5ºC at 760mmHg |
| Storage Condition | 2-8°C, store in inert gas |
| Application | AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and encephalomyocar |
| HTC | 2933990090 |
| MDL Number | MFCD06804597 |
| SMILES | COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC.Cl |
| InChI | InChI=1S/C16H14ClN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H |
| InChI Key | WDJDYIUSDDVWKB-UHFFFAOYSA-N |
| MSDS | msds/75883_1_170449_18_0.pdf |
| Use of | AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and encephalomyocarditis virus (EMCV)[1][2][3][4]. Properties Name N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride Synonym More Synonyms AG 1478 hydrochloride Biological Activity Description AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and encephalomyocarditis virus (EMCV)[1][2][3][4]. Related Catalog Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Research Areas >> Cardiovascular Disease Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Research Areas >> Metabolic Disease EGFR:3 nM (IC50) References [2]. Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580. [3]. Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215. [4]. Dorobantu CM, et al. Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6402-6. Chemical & Physical Properties Exact Mass 351.054138 PSA 56.27000 LogP 4.91900 InChIKey WDJDYIUSDDVWKB-UHFFFAOYSA-N Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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