![(R)-2-(1-(7-Methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoicacid structure, CAS 1173900-33-8](/structures/80000/75871_1_1173900_33_8.png)
CAS Number1173900-33-8
Synonyms2-({(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl}amino)benzoic acid; AZD6482; AZD 6482
Molecular FormulaC22H24N4O4
Molecular Weight408.45
Purity≥98 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point635.5±65.0 °C at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1173900-33-8 |
| Catalog No. | 2A-9075871 |
| Chinese Name | 2-[[(1R)-1-[7-甲基-2-(4-吗啉)-4-氧代-4H-吡啶并[1,2-A]嘧啶-9-基]乙基]氨基]苯甲酸 |
| Synonyms | 2-({(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl}amino)benzoic acid; AZD6482; AZD 6482 |
| Molecular Formula | C22H24N4O4 |
| Molecular Weight | 408.45 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 635.5±65.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | Room temperature, dry, sealed |
| Application | AZD 6482 is a potent and selective p110β inhibitor with an IC50 of 0.69 nM. |
| HTC | 2934999090 |
| PubChem ID | 85093417 |
| MDL Number | MFCD16659062 |
| SMILES | [n]21c(nc(c[c]2=O)N4CCOCC4)c(cc(c1)C)[C@H](Nc3c(cccc3)C(=O)O)C |
| InChI | 1S/C22H24N4O4/c1-14-11-17(15(2)23-18-6-4-3-5-16(18)22(28)29)21-24-19(12-20(27)26(21)13-14)25-7-9-30-10-8-25/h3-6,11-13,15,23H,7-10H2,1-2H3,(H,28,29)/t15-/m1/s1 |
| InChI Key | IRTDIKMSKMREGO-OAHLLOKOSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/75871_1_1173900_33_8.pdf |
| Use of | AZD 6482 is a potent and selective p110β inhibitor with IC50 of 0.69 nM. Properties Name 2-[[(1R)-1-(7-methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoic acid Synonym More Synonyms AZD6482 Biological Activity Description AZD 6482 is a potent and selective p110β inhibitor with IC50 of 0.69 nM. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer PI3Kα:136 nM (IC50) PI3Kβ:0.69 nM (IC50) PI3Kδ:13.6 nM (IC50) PI3Kγ:47.8 nM (IC50) PI3K-C2β:54.1 nM (IC50) hVps34:3390 nM (IC50) DNA-PK:53.7 nM (IC50) PI4Kα:8830 nM (IC50) mTOR:3930 nM (IC50) Kinase Assay AZD 6482 (KIN-193) is profiled at a concentration of 10 µM against a diverse panel of 433 kinases. Scores for primary screen hits are reported as percent of the DMSO control (% control). For kinases where no score is shown, no measurable binding is detected. The lower the score, the lower the Kd is likely to be, such that scores of zero represent strong hits. Scores are related to the probability of a hit, but are not strictly an affinity measurement. At a screening concentration of 10 µM, a score of less than 10% implies that the false positive probability is less than 20% and the Kd is most likely less than 1 µM. A score between 1-10% implies that the false positive probability is less than 10%, although it is difficult to assign a quantitative affinity from a single-point primary screen. A score of less than 1% implies that the false positive probability is less than 5% and the Kd is most likely less than 1 µM[1]. Cell Assay Cell viability is determined. Briefly, cells are seeded in medium containing 5% FBS at a density insuring cell growth throughout drug treatment (~15% for most cell lines). Drug treatment is started 24 h post seeding and continued for 72 h. Cell are fixed and stained using Syto60, a red fluorescent DNA stain. The relative cell number is calculated by taking the ratio of the relative fluorescence intensity from drug treated wells over untreated wells after background subtraction (cells-free wells). Nine doses of AZD 6482 (KIN-193) are used in 2-fold dilution steps ranging from 5.12 µM to 0.02 µM. IC50, corresponding to 50% cell number compared to control (untreated) wells, is determined using a fixed top and bottom sigmoidal fitting algorithm implemented in PipelinePilot[1]. References [1]. Ni J, et al. Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2012 May;2(5):425-33. Chemical & Physical Properties Molecular Formula C22H24N4O4 Exact Mass 408.179749 PSA 96.17000 Index of Refraction 1.664 InChIKey IRTDIKMSKMREGO-OAHLLOKOSA-N Safety Information Hazard Codes Xi HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Pharmaceutical Intermediates | ||
|---|---|---|
| (S)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]pyrrolidine | 169750-01-0 | 2A-9075833 |
| N-Boc-T-Butylglycine | 169870-82-0 | 2A-9075846 |
| 4-Piperidinylcarboxamidinehydrochloride | 1170937-23-1 | 2A-9075854 |
| (S)-2-Amino-3-cyclohexylpropan-1-olhydrochloride | 117160-99-3 | 2A-9075858 |
| (R)-3-Boc-Aminobutylamine | 170367-69-8 | 2A-9075868 |
| 1-(4-Morpholinyl)-2-(4-bromo-1H-pyrazol-1-yl)ethanone | 1178206-51-3 | 2A-9075884 |
| (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide | 135729-78-1 | 2A-9075885 |
| Imidazo[1,2-a]pyridine-2-carbaldehyde | 118000-43-4 | 2A-9075893 |
| 2-(2-AminoEthyl)-4(3H)-quinazolinonemonohydrochloride | 1185298-40-1 | 2A-9075908 |
| (S)-2-(3,4-Dihydro-1H-isochromen-1-yl)aceticacid | 170856-84-5 | 2A-9075913 |
| Browse all Pharmaceutical Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS